甘草酸类药物治疗自身免疫性肝炎疗效分析

To investigate efficacy of glycyrrhizin therapy for autoimmune hepatitis (AIH) .We analyzed the levels of liver function and efficacy after glycyrrhizin therapy (including monoammonium glycrrhizinate, diammonium glycyrrihizinate and compound glycyrrhizin) for 79 cases with AIH retrospectively.21 cases treated with corticosteroid served as control.After treatment, the level of ALT, AST and TBil descended markedly in all of the four groups (P<0.05.The complete responder rate in the glycyrrhizin groups and corticosteroid group was 78.2%、81.6%、82.7% and 83.3% respectively.There was no significant deference between the four groups.The efficacy rate of Type Ⅰ and Ⅲ AIH in two groups were higher than that of Type Ⅱ AIH (P<0.05) .Glycyrrhizin therapy for autoimmune hepatitis has the similar shortternm efficacy as comcosteroid.But the longer-term efficacy of dycyrrhizin therapy for autommune hepatitis need further evaluated.