Objective To observe the effect of combined application of anti-HB transfer factor and Adefovir in treating patients with chronic hepatitis B (CHB) and its influence on HBV DNA.Methods 184 patients were enrolled and randomized into two groups: the treated grorp (92 cases) and control group (92cases) .The treated group received anti-HB transfer factor and Adefovir simultaneously for 12 months.The control group received Adefovir alone for 12 months Liver function, virological parameters, serum HBV DNA and HBV DNA were evaluated.Liver biopsy was taken before therapy and after 12 months treament in 40patients.Results After 12months treatment, there was no difference in HBV DNA negative rate between treated group and control groups (P>0.05) .Most of liver histology were improved in 40 patients.Conclusions Combined application of anti-HB transfer factor and 1 Adefovir could enhance the therapeutic effect in treating CHB to certain extent, but effect on HBV DNA should be study further more.
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