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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 40 Issue 10
Oct.  2024
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Article Navigation >  Journal of Clinical Hepatology  > 2024  >  40(10): 1954-1958

Research advances in the pathogenesis of metabolic associated fatty liver disease

DOI: 10.12449/JCH241005

  • Department of Gastroenterology，China-Japan Friendship Hospital，Beijing 100029，China

Research funding:

Joint Fund Project of Biomedical Translational Engineering Research Center of Beijing University of Chemical Technology and China-Japan Friendship Hospital (XK2022-07)

More Information
  • Corresponding author: YAO Shukun， shukunyao@126.com （ORCID： 0000-0002-8512-2589）
  • Received Date: 2024-08-23
  • Accepted Date: 2024-09-10
  • Published Date: 2024-10-25
    Abstract
  • Metabolic associated fatty liver disease （MAFLD） is currently the most common liver disease around the world. MAFLD may easily progress to the adverse outcomes such as hepatitis， liver fibrosis， and liver cirrhosis， and it is often accompanied by comorbidities such as diabetes， hypertension， hyperlipidemia， hyperuricemia， and cardiovascular and cerebrovascular diseases. Etiological treatment is the cornerstone of MAFLD treatment， and due to the complexity and adverse outcome of MAFLD， it is of great significance to explore the pathogenesis of MAFLD and develop effective prevention and treatment regimens and drugs. This article reviews the pathogenesis of MAFLD from the aspects of genetic factors， improper diet and oxidative stress， spleen-stomach damp-heat and insulin resistance， damp-heat and pathogenic Qi， organic acid metabolism， and intestinal microecology.

     

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