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Volume 41 Issue 1
Jan.  2025
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Article Navigation >  Journal of Clinical Hepatology  > 2025  >  41(1): 24-29

Effect of hepatitis B virus integration on functional cure

DOI: 10.12449/JCH250104

  • Research Laboratory of Clinical Virology，Department of Infectious Diseases，Ruijin Hospital，Shanghai Jiao Tong University School of Medicine，Shanghai 200025，China

Research funding:

National Natural Science Foundation of China Young Scientist Fund (82402601);

General Project of Natural Science Foundation of Shanghai (24ZR1448400)

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  • Corresponding author: ZHANG Xinxin， zhangx@shsmu.edu.cn （ORCID： 0000-0002-0598-6425）
  • Received Date: 2024-11-19
  • Accepted Date: 2024-12-17
  • Published Date: 2025-01-25
    Abstract
  • Functional cure is currently recommended by guidelines as the ideal treatment goal for the prevention and treatment of chronic hepatitis B （CHB） in China and globally， and it is defined as sustained and undetectable serum HBsAg and HBV DNA， HBeAg clearance， and presence or absence of HBsAg seroconversion， accompanied by resolution of liver inflammation， histopathological improvements， and a significant reduction in the incidence rate of end-stage liver disease. HBV can integrate into the host genome and contribute to the continuous production of HBsAg， which can occur in the early stage of chronic HBV infection. In addition to the covalently closed circular DNA that is hard to be eliminated in liver tissue， HBsAg derived from HBV integration independent of viral replication may be the most important factor for the difficulty in achieving functional cure after antiviral therapy in patients with hepatitis B. This article reviews the research advances in HBV integration in recent years and discusses its impact on functional cure.

     

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