Analysis of ERα-29 polymorphisms between Han nationality and Hui minority populations with chronic hepatitis B in Gansu Province, China

Objective To investigate the genetic polymorphisms in the estrogen receptor (ER) alpha gene at position 29 (ERα-29) in patients with chronic hepatitis B (CHB) from Han nationality and Hui minority populations in Gansu Province, China. Methods Polymorphisms of ERα-29 were analyzed in 84 Han and 84 Hui CHB patients who were admitted to our hospital from August 2012 to November 2013 by polymerase chain reaction-restriction fragment length polymorphism analysis. Allele frequencies were determined by gene counting and tested for expectations of Hardy-Weinberg equilibrium. Unconditional logistic regression analysis was applied to adjust the confounding factors. Comparison of the genotype and allele frequencies was performed by chi-square test. Results The genotype frequencies of ERα-29 in Han versus Hui CHB patients from Gansu Province were as follows: TT, 52. 4% vs 60. 7%; TC, 40. 5% vs 34. 5%; CC, 7. 1% vs 4. 8%. The allele frequencies were 72. 6% vs 78. 0% for the T allele and 27. 4% vs 22. 0% for the C allele. No significant differences in the allele and genotype frequencies of ERα-29 were found between Han and Hui CHB patients in Gansu Province (P > 0. 05) . Conclusion The genetic polymorphisms in ERα-29 are not significantly different between Han and Hui CHB patients in Gansu Province, China.