Current status of the pathogenesis, diagnosis, and treatment of drug-induced cholestasis

Liu Meng; Yang XuanZi; Yu LeCheng

doi:10.3969/j.issn.1001-5256.2019.02.003

Volume 35 Issue 2

Feb. 2019

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Article Navigation > Journal of Clinical Hepatology > 2019 > 35(2): 252-257

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Current status of the pathogenesis, diagnosis, and treatment of drug-induced cholestasis

DOI: 10.3969/j.issn.1001-5256.2019.02.003

General Hospital of Eastern Theater Command & Bayi Hospital Affiliated to Nanjing University of Chinese Medicine

Received Date: 2018-12-12
Published Date: 2019-02-20

Abstract

Abstract

Drug-induced cholestasis ( DRIC) mainly includes cholestasis-type and mixed-type drug-induced liver injury ( DILI) . The Roussel Uclaf Causality Assessment Method scale should be used to determine the causality between drug and cholestasis and other etiologies should be excluded. Liver biopsy may help with differential diagnosis. Drugs should be stopped after the development of DRIC to avoid stimulation, and ursodeoxycholic acid should be administered for treatment. DRIC has a complex pathogenesis, which involves the direct toxicity of drugs and their metabolites on hepatocytes and the biliary tree, immune and inflammatory response, gene polymorphism and inhibition of key enzymes and transporters in the pathways of drug metabolism and efflux, and HLA gene polymorphisms. Clarification of these pathogeneses helps with the early warning, prevention, and optimized treatment of DRIC.
- drug-induced liver injury,
- cholestasis,
- diagnosis,
- therapeutics

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References(39)

References

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Current status of the pathogenesis, diagnosis, and treatment of drug-induced cholestasis

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Current status of the pathogenesis, diagnosis, and treatment of drug-induced cholestasis

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