Risk factors for hepatocellular carcinoma in patients with chronic hepatitis B

Long LIU; Ke SHI; Qun ZHANG; Chongping RAN; Jie HOU; Yi ZHANG; Xianbo WANG

doi:10.3969/j.issn.1001-5256.2021.07.022

Volume 37 Issue 7

Jul. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(7): 1589-1593

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Risk factors for hepatocellular carcinoma in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2021.07.022

Long LIU¹,
Ke SHI^{1, 2},
Qun ZHANG¹,
Chongping RAN¹,
Jie HOU^{1, 2},
Yi ZHANG¹,
Xianbo WANG^{1
,
,}

1.
Department of Integrative Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
2.
The First Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100700, China

Research funding:

Capital Health Development Research Project (2018-1-2172);

Beijing Municipal Commission of Science and Technology (Z191100006619033);

National Administration of Traditional Chinese Medicine Clinical Cooperation Pilot Project of Traditional Chinese and Western Medicine for Major and Difficult Diseases (2018-6-4);

Regional TCM Diagnosis and Treatment Center of State Administration of Traditional Chinese Medicine (2019-3-18)

Received Date: 2021-01-02
Accepted Date: 2021-02-10
Published Date: 2021-07-20

Abstract

Abstract

Objective To investigate the risk factors for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Methods A total of 1239 patients who were diagnosed with CHB in Beijing Ditan Hospital from January 2013 to June 2015 and were followed up for more than 3 years were enrolled, among whom 1108 had no liver cirrhosis and 131 had liver cirrhosis. General information and laboratory markers were collected. The chi-square test was used for comparison of categorical data between groups, and the t-test or the Mann-Whitney U test was used for comparison of continuous data between groups. The t-test was used for comparison of normally distributed continuous data between two groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test for comparison of categorical data between two groups. A multivariate Cox regression analysis was used to identify the independent risk factors for HCC. The area under the ROC curve (AUC) was used to compare the ability of fibrosis-4 (FIB-4), modified FIB-4 (mFIB-4), and aspartate aminotransferase-to-platelet ratio index (APRI) scores to predict the development of HCC, and the DeLong test was used for comparison of AUC. Goodness of fit was used to evaluate the calibration ability of mFIB-4 score. The Kaplan-Meier method was used to analyze the development of HCC, and the log-rank test was used for comparison. Results The median follow-up time was 4.6 years, and of all patients, 37 (3.0%) developed HCC. The multivariate Cox regression analysis showed that age (hazard ratio [HR]=1.046, 95% confidence interval [CI]: 1.018-1.074, P=0.001), alanine aminotransferase (ALT) (HR=0.995, 95%CI: 0.992-0.999, P=0.008), aspartate aminotransferase (AST) (HR=0.994, 95%CI: 0.990-0.998, P=0.020), and platelet count (PLT) (HR=0.988, 95%CI: 0.981-0.994, P=0.001) were independent risk factors for HCC in CHB patients. The mFIB-4, FIB-4, and APRI scores had an AUC of 0.771, 0.658, and 0.676, respectively, and mFIB-4 score had a significantly higher AUC than FIB-4 score (Z=5.629, P < 0.000 1) and APRI score (Z=4.243, P < 0.000 1). Compared with the patients with mFIB-4 < 2.68, the patients with mFIB-4 ≥2.68 had a significantly higher risk of HCC (Z=37.840, P < 0.000 1). Conclusion Age, ALT, AST, and PLT are independent risk factors for HCC in CHB patients. Compared with FIB-4 and APRI scores, mFIB-4 s core has a higher value in predicting HCC in CHB patients. The patients with mFIB-4 ≥2.68 are the high-risk population of HCC.
- Chronic Hepatitis B,
- Carcinoma, Hepatocellular,
- Risk Factors,
- Liver Fibrosis Score

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References(28)

References

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Risk factors for hepatocellular carcinoma in patients with chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2021.07.022