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Volume 39 Issue 8
Aug.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(8): 2005-2011

Research advances in the mechanism of tumor microenvironment and targeted therapy for pancreatic neuroendocrine tumor

DOI: 10.3969/j.issn.1001-5256.2023.08.036

  • Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, National Key Clinical Specialty, Yunnan Province Clinical Research Center for Digestive Diseases, Kunming 650032, China

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  • Corresponding author: ZHANG Hairong, zhr919@sina.com (ORCID: 0000-0002-9918-3673)
  • Received Date: 2022-10-26
  • Accepted Date: 2022-11-29
  • Published Date: 2023-08-20
    Abstract
  • The tumor microenvironment of pancreatic neuroendocrine tumor is a tumor-promoting microenvironment composed of tumor cells, immune/immunosuppressive cells, and extracellular matrix and has the marked feature of immunosuppression. It can lead to the immune escape, invasion, and metastasis of tumor cells by inhibiting antitumor immune response and promoting angiogenesis and is also the main cause of drug resistance to antitumor treatment. Therefore, it is of great significance to design new therapeutic strategies from the perspective of the tumor microenvironment of pancreatic neuroendocrine tumor to reverse suppressive tumor microenvironment and improve the treatment outcome of pancreatic neuroendocrine tumor. This article reviews the latest research advances in the composition and role of the tumor microenvironment of pancreatic neuroendocrine tumor and related targeted therapy.

     

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