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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 39 Issue 12
Dec.  2023
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Article Navigation >  Journal of Clinical Hepatology  > 2023  >  39(12): 2952-2958

Regulatory role of mechanical forces in the formation of liver organoids

DOI: 10.3969/j.issn.1001-5256.2023.12.030

  • Department of Infectious Diseases，Guang’anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China

Research funding:

National Natural Science Foundation of China (81774282);

National Key Research and Development Program of China (2018YFC1705700);

Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences (C12021A00801);

Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences (C12021A00802)

More Information
  • Corresponding author: LYU Wenliang， lvwenliang@sohu.com （ORCID： 0000-0002-4552-919X）
  • Received Date: 2023-03-24
  • Accepted Date: 2023-04-19
  • Published Date: 2023-12-12
    Abstract
  • In recent years， the continuous advances in material sciences and techniques have helped with the establishment and development of liver organoids that can simulate the structure and function of organs in vivo. In addition to the research on traditional biological factors， the construction of microenvironments with different mechanical cues to investigate the influence of mechanical stimulation on the growth of liver organoids has also become a research focus. This article first discusses the development of liver organoids and then reviews the influence of mechanical forces of different properties on the formation of liver organoids， so as to lay a foundation for the construction of more complex and ordered liver organoids in vitro and provide ideal research models for understanding the interaction between biological and mechanical factors in the formation of liver organoids.

     

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