拉米夫定联合卡托普利治疗166例慢性乙型肝炎患者的抗肝纤维化疗效分析

Objective To study the effect of inhibiting fibrosis of combination treatment with Lamivudine and Captopril on CHB (chronic hepatitis B) .Methods 166 cases with CHB, who were divided into reducing-liver enzyme group, Lamivudine group, Captopril group and combination group with Lamivudine and Captopril according to different therapeutic strategy used on them, were analyzed retrospectively.And the levels of four blood markers and histologic stages on hepatic fibrosis of these cases were evaluated.Results The levels of the four blood markers declined in varying degrees after treatment compared with those before treatment in combination group, Lamivudine group, and Captopril group respectively.At the same time, the rates of histologic stage 0-1 rose remarkably, while the rates of stage 2-3 and stage 4 descended markedly.There were not significant statistic difference between in the levels of the four blood markers and histologic stages in reducing-liver enzyme group before and after treatment.Conclusion Both Lamivudine and Captopril had effect on inhibiting hepatic fibrosis in CHB patients.This effect was more evident when treating CHB with combining Lamivudine with Captopril.