Abnormal activation of the insulin-like growth factor-I receptor (IGF-IR) occurs during malignant transformation of hepatocytes and during hepatocarcinogenesis.IGF-IR overexpression has been proposed as a diagnostic biomarker for early-stage hepatocellular carcinoma (HCC) as well as a novel target for HCC therapy.This review summarizes the recent research of the IGF-IR signaling pathway's abnormal activation in HCC and the results of molecular targeting studies.
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