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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2016
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Predictive value of HBs Ag quantification in pegylated interferon therapy for chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2016.05.041
  • Published Date: 2016-05-20
  • Antiviral therapy is the most important thing in the treatment of chronic hepatitis B( CHB). Pegylated interferon( PEG- IFN)has both antiviral and immunomodulatory effects,and after drug withdrawal,30%- 40% of patients can achieve HBe Ag seroconversion and sustained virologic response. Many studies have shown that HBs Ag quantification can be used as an index to predict the anti- HBV effect of PEG- IFN and sustained immune control after drug withdrawal. This article reviews the relationship between HBs Ag levels before,during,and after PEG- IFN therapy and antiviral effect to clarify the significance of HBs Ag quantification in the PEG- IFN treatment of CHB and to guide the regimen of antiviral therapy.

     

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