Nonalcoholic fatty liver disease( NAFLD) is a multisystem disease involving metabolic disorder and is more common in patients with obesity and type 2 diabetes mellitus( T2 DM),with similar adverse outcomes to these two comorbidities. For a long time,NAFLD has emphasized liver lesions and outcomes of...

The terms nonalcoholic steatohepatitis and nonalcoholic fatty liver disease( NAFLD) were first used in the 1980 s to describe a condition of similar liver histological changes to alcoholic liver disease,without excessive drinking nor other factors for liver injury. In-depth research on NAFLD has ach...

Although nonalcoholic fatty liver disease( NAFLD) is a liver disease,it has attracted more and more attention among endocrinologists. There are complex interactions between the metabolic status of diabetes and the pathology of NAFLD,and they promote the development of each other. In the population w...

Nonalcoholic fatty liver disease( NAFLD) is associated with a 2-to 3-fold increase in the risk of developing type 2 diabetes( T2 DM) in non-diabetic patients,and therefore,the NAFLD population is considered a large population at a high risk of T2 DM. In the population diagnosed with T2 DM,the preval...

Nonalcoholic steatohepatitis( NASH)/nonalcoholic fatty liver disease( NAFLD) has gradually become one of the main causes of hepatocellular carcinoma( HCC) in Western developed countries. Different from the typical evolution process of hepatitis,liver cirrhosis,and liver cancer,nearly 40% NAFLD patie...

Nonalcoholic fatty liver disease( NAFLD) is the most common type of liver disease in developed countries,and in recent years,the prevalence rate of NAFLD tends to increase in China,which brings heavy burden to the social health system. The development and progression of NAFLD are affected by the int...

The prevention and treatment of COVID-19 nationwide has entered a tackling phase. Effective treatment of severe and critically ill patients is the key to reducing the fatality of the disease. The artificial liver blood purification system can remove inflammatory factors,alleviate the damage of the i...

Distal biliary stricture is a biliary lesion commonly seen in clinical practice and can be caused by benign and malignant diseases.Although endoscopic technique has become a major treatment method for distal biliary stricture,there is still a lack of comprehensive understanding of this condition. Th...

Objective To investigate the pattern of drug resistance mutations of the genes in the reverse transcriptase( RT) region and its association with clinical features in patients with hepatitis B virus( HBV) infection in Xuzhou,Jiangsu,China,as well as the influencing factors for drug resistance. Method...

Objective To investigate the expression features of glucocorticoid receptor( GR) and its subtypes α and β in patients with early-or middle-stage hepatitis B virus-related acute/subacute-on-chronic liver failure( HBV-ACLF) treated by glucocorticoid( GC) and their association with sensitivity to gluco...

Objective To investigate the value of the COSSH-ACLFs model in predicting the short-term( 90-day) prognosis of patient with hepatitis B virus-related acute-on-chronic liver failure( HBV-ACLF). Methods A total of 573 patients who were diagnosed with HBV-ACLF in The Affiliated Hospital of Southwest Me...

Objective To investigate the real-world viral response of chronic hepatitis C( CHC) patients receiving direct-acting antiviral agent( DAA) treatment and its effect on liver stiffness measurement( LSM) and aspartate aminotransferase-to-platelet ratio index( APRI). Methods The CHC patients who were co...

Objective To investigate the value of transient elastography( FibroScan) in the diagnosis of liver fibrosis in chronic hepatitis B( CHB) children of different ages. Methods A total of 280 CHB children,aged < 18 years,who were hospitalized in The Fifth Medical Center of Chinese PLA General Hospita...

Objective To investigate the clinical effect of terlipressin combined with somatostatin in the treatment of esophagogastric variceal bleeding( EVB) in patients with liver cirrhosis. Methods A retrospective analysis was performed for the clinical data of 73 patients with liver cirrhosis and EVB who w...

Objective To investigate the value of Child-Pugh score,Model for End-Stage Liver Disease( MELD) score,MELD combined with serum sodium concentration( MELD-Na score),APASAL score,and R-score in predicting rebleeding and death in cirrhotic patients with esophagogastric variceal bleeding. Methods The pa...

Objective To investigate the expression of the N-myc downstream regulated gene( NDRG) family in hepatocellular carcinoma( HCC) and its association with pathological features and prognosis based on bioinformatics mining. Methods The expression of the NDRG family and the survival data of patients with...

Objective To investigate the effect of extracellular ubiquitin on the proliferation,invasion,and migration of hepatoma cells by in vitro cell experiments. Methods The hepatoma cells( HepG2) were treated with extracellular ubiquitin at different concentrations( 200,400,and 800 ng/ml); CCK-8 assay was...

Objective To investigate the association of the clinical features of liver cancer patients,including albumin-bilirubin( ALBI)and neutrophil-lymphocyte ratio( NLR),with the traditional Chinese medicine( TCM) syndrome types of primary liver cancer,and to establish a clinical judgment model for TCM syn...

Objective To investigate the association between nonalcoholic fatty liver disease( NAFLD) and colorectal adenomatous polyps and the correlation of NAFLD severity with the risk of colorectal adenomatous polyps. Methods A total of 67 patients with colorectal adenomatous polyps who were hospitalized in...

Objective To investigate the association between nonalcoholic fatty liver disease( NAFLD) and epicardial adipose tissue( EAT). Methods Databases including PubMed,Embase,Web of Science,Wanfang Data,and CNKI were searched for the articles on the association of thickness and volume of EAT with NAFLD pu...

Objective To investigate the metabolic characteristics of nonalcoholic fatty liver disease( NAFLD) and related risk factors in non-obese population. Methods A retrospective analysis were performed for 12 125 individuals who underwent physical examination in Physical Examination Center of PLA Rocket ...

Objective To investigate whether abdominal obesity and hypertriglyceridemia have a synergistic effect on the development of nonalcoholic fatty liver disease( NAFLD). Methods A prospective cohort study was conducted. Physical examination data were collected from 70 776 on-the-job or retired employees...

Objective To investigate the association between liver fibrosis and serum uric acid in patients with type 2 diabetes mellitus( T2 DM) and nonalcoholic fatty liver disease( NAFLD). Methods A total of 328 patients with T2 DM and NAFLD who attended Cangzhou People's Hospital from January 2018 to August...

Objective To investigate the association between microRNA-155( miR-155)/SH2-containing inositol phosphatase-1( SHIP-1) and cardiovascular events in patients with nonalcoholic fatty liver disease( NAFLD). Methods A total of 104 patients with NAFLD who were admitted to our hospital from March 2018 to ...

Objective To investigate the clinical effect and safety of magnesium isoglycyrrhizinate in the treatment of autoimmune-like drug-induced liver injury. Methods A total of 53 patients with autoimmune-like drug-induced liver injury who were hospitalized in Beijing YouAn Hospital,Capital Medical Univers...

Objective To investigate the changes in the expression of semaphorin 3 A( Sema3 A) and receptor neuropilins-1( NRP-1) in the prefrontal cortex and the hippocampal CA1,CA3,and DG regions in rats with hepatic encephalopathy( HE) and their possible significance. Methods A total of 40 Sprague-Dawley rat...

Objective To screen out the scoring system with the highest predictive value by analyzing the comprehensive scoring systems which can assess the severity and prognosis of acute pancreatitis in the early stage( within 24 hours) after admission. Methods A retrospective analysis was performed for the c...

Nucleos( t) ide analogues( NAs) are effective inhibitors for HBV replication and have become the preferred antiviral regimen for most patients with chronic hepatitis B( CHB). HBeAg seroconversion is an important index used to evaluate the durability and efficacy of antiviral therapy in HBeAg-positiv...

Liver cirrhosis is a pathological stage in which most chronic liver diseases progress to the advanced stages,and the main complications of liver cirrhosis include portal hypertension,gastroesophageal variceal bleeding,and liver cancer. Transient elastography( TE) uses acoustic waves to obtain liver ...

Hepatic fat content is an important index for the early diagnosis,disease grading,and outcome evaluation of nonalcoholic fatty liver disease( NAFLD). Various magnetic resonance imaging( MRI) methods have been used to determine hepatic fat content in NAFLD,among which proton density fat fraction obta...

Nonalcoholic fatty liver disease( NAFLD) has replaced viral hepatitis and become the most important chronic liver disease in the world. Abdominal ultrasound remains the main method for the diagnosis of NAFLD in China. The studies in China showed that in the last two decades,the prevalence rate of NA...

Enterohepatic circulation plays an important role in the pathogenesis of nonalcoholic fatty liver disease( NAFLD). Bile acid is the basic substance of enterohepatic circulation and plays an important role in lipid metabolism,intestinal flora regulation,and host immunity. This article summarizes the ...

Recent studies have shown that intestinal flora can play a role in the treatment of nonalcoholic fatty liver disease( NAFLD),and intestinal flora regulation can provide new thoughts for the treatment of NAFLD. This article reviews the research advances in the role of intestinal flora regulation in t...

Recent studies have found that visfatin is involved in lipid metabolism in patients with nonalcoholic fatty liver disease( NAFLD),and about 25% of NAFLD patients have thyroid dysfunction. It has also been found that visfatin is involved in autoimmune regulation through the autocrine or paracrine pat...

In recent years,immune checkpoint inhibitor( ICI) in the treatment of unresectable liver cancer has attracted great attention in China and foreign countries and great progress has been achieved,but ICI monotherapy cannot bring benefits to most patients with liver cancer. Therefore,it is a new trend ...

At present,there is still a lack of uniform treatment strategies for hepatocellular carcinoma( HCC). Immunotherapy,especially PD-1/PD-L1 checkpoint inhibitors,is a novel therapy for HCC and can bring survival benefits to patients with advanced HCC. However,research data show that only a small number...

Hepatic macrophages are an important cell component in the natural immune system. In the physiological environment,they can recognize and eliminate necrotic or apoptotic cell fragments,pathogens,and presenting antigens and participate in adaptive immunity and immune surveillance,while in the patholo...

Primary biliary cholangitis( PBC) is a chronic autoimmune liver disease characterized by progressive destruction of the small intrahepatic bile ducts. Patients with PBC often have extrahepatic autoimmune diseases,which can involve multiple organs and systems including the gastrointestinal tract,lung...

The outbreak of viral pneumonia caused by severe acute respiratory syndrome coronavirus 2( SARS-CoV-2) in Wuhan,China poses a major threat to public health. SARS-CoV-2 is highly homologous to severe acute respiratory syndrome-associated coronavirus and Middle East respiratory syndrome-associated cor...

Severe liver disease during pregnancy is uncommon in clinical practice. The most common cause of liver disease during pregnancy is liver dysfunction,with an overall prevalence rate of approximately 3%. Liver disease during pregnancy is classified into the liver diseases directly caused by pregnancy ...

Sarcopenia is a component of malnutrition in patients with liver cirrhosis. Studies have shown that both sarcopenia and hepatic encephalopathy can reduce quality of life and increase the risk of adverse events,including death,in patients with liver cirrhosis. This article reviews the association bet...

Liver failure is a syndrome of severe liver diseases commonly seen in clinical practice,and it has a high mortality rate and thus becomes one of the critical diseases in internal medicine. Massive hepatocyte death and the extent of hepatocyte death exceeding the liver's regenerative capacity are con...

At present,the epidemic of coronavirus disease 2019 is still serious,and the prevention and control of this epidemic is taken seriously throughout the country. As one of the most common acute abdominal diseases in hepatobiliary surgery,gallstones with acute cholecystitis has sudden onset and rapid p...

Hemolytic jaundice has various etiologies and clinical manifestations. Although some patients have hemolysis,they may have jaundice as the initial manifestation due to unobvious or mild anemia,and the disease may last for a long time with difficulties in treatment and can be misdiagnosed as unexplai...

Severe acute pancreatitis( SAP) is a disease with dangerous course and poor prognosis,and although medical technology keeps improving over the years,the mortality rate of SAP remains high. As the latest achievement in the field of blood purification over the past 30 years,continuous blood purificati...