2024 No. 2

Vol.40 No.2 (280 in total) Feb. 2024

Theme Issue: Clinical Practice and Research Advances in Artificial Liver Support Therapy

Executive Chief Editor: HAN Tao

Tianjin People's Hospital, Tianjin Union Medical Center Affiliated to Nankai University

Cover Content

Previous Issue | Next Issue

Select articles

Display Method:

Editorial

Clinical practice and research advances in artificial liver support therapy

Tao HAN, Qian ZHANG

2024, 40(2): 225-228. DOI: 10.12449/JCH240201

Abstract(839)

HTML (485)

PDF (546KB)(216)

Abstract:
Artificial liver support system is one of the important therapies for liver failure， and in recent years， the role of non-bioartificial liver support system in the treatment of liver failure has been gradually recognized， with wide application in non-liver failure diseases. In clinical practice， var...

Expert Forum

Artificial liver support therapy for patients with pre-liver failure

Jing ZHANG, Xinmin ZHOU

2024, 40(2): 229-232. DOI: 10.12449/JCH240202

Abstract(441)

HTML (284)

PDF (540KB)(139)

Abstract:
Liver failure is a common clinical syndrome of severe liver disease with rapid progression and high mortality. Therefore， early intervention in pre-liver failure or “golden window” is of great significance in improving the prognosis of patients. Hepatitis B virus-related acute-on-chronic liver failu...

Research advances in combined artificial liver

Yue HUANG, Hong PENG, Xinhua LUO

2024, 40(2): 233-238. DOI: 10.12449/JCH240203

Abstract(587)

HTML (152)

PDF (614KB)(115)

Abstract:
At present， in vitro artificial liver support system has achieved a good therapeutic effect in the diseases such as liver failure due to various causes， non-function state before and after liver transplantation， and severe cholestasis. Non-bioartificial liver （NBAL） is widely used in clinical practi...

Optimization of non-bioartificial liver technology and research advances in biological artificial liver

Li ZHOU, Yanrong YANG, Yu CHEN

2024, 40(2): 239-245. DOI: 10.12449/JCH240204

Abstract(534)

HTML (365)

PDF (693KB)(107)

Abstract:
Liver failure is a common clinical syndrome with rapid progression and poor prognosis. Currently， there are still limited internal medical treatment methods for liver failure， and artificial liver support therapy is an effective treatment method. Non-bioartificial liver technology is widely used in ...

Source and application of seed cells in bioartificial liver support system

Xuejing ZHU, Weijian HUANG, Hexin YAN

2024, 40(2): 246-251. DOI: 10.12449/JCH240205

Abstract(671)

HTML (104)

PDF (877KB)(85)

Abstract:
So far， there are still no specific treatment methods for severe hepatitis and liver failure， resulting in a mortality rate of over 70%， and they are the difficulties in the treatment of critical illness in China and globally. Liver transplantation is currently the most effective treatment method fo...

Guideline

An excerpt of European Society for Organ Transplantation consensus statement on biomarkers in liver transplantation （2023）

Yi BAI, Jinming LI, Yamin ZHANG

2024, 40(2): 252-257. DOI: 10.12449/JCH240206

Abstract(438)

HTML (221)

PDF (615KB)(79)

Abstract:
In August 2023， the European Society for Organ Transplantation （ESOT） published the ESOT Consensus Statement on Biomarkers in Liver Transplantation online. The consensus statement focuses on biomarkers in liver transplantation， clinical applicability， and future needs and explores the role of new bi...

Viral Hepatitis

Clinical features of critically ill pregnant and parturient women infected with chronic hepatitis B virus： An analysis of 41 cases

Yuhao JU, Wen LI, Yu WANG, Lingyan XIAO, Yishan ZHENG, Guorong HAN

2024, 40(2): 258-263. DOI: 10.12449/JCH240207

Abstract(471)

HTML (169)

PDF (670KB)(68)

Abstract:
Objective To investigate the clinical features and outcomes of critically ill pregnant and parturient women with chronic hepatitis B virus （HBV） infection， and to provide clinical experience for the rescue of critically ill pregnant and parturient women and the prevention and treatment of the severe...

Value of serum creatinine-to-cystatin C ratio in assessing the prognosis of hepatitis B virus-related acute-on-chronic liver failure

Daqing LIU, Yan HUANG, Jianhe GAN

2024, 40(2): 264-270. DOI: 10.12449/JCH240208

Abstract(514)

HTML (156)

PDF (799KB)(59)

Abstract:
Objective To investigate the clinical value of serum creatinine-to-cystatin C ratio （CCR） in evaluating the prognosis of hepatitis B virus-related acute-on-chronic liver failure （HBV-ACLF）. Methods A retrospective analysis was performed for the clinical data of 130 patients with HBV-ACLF （treatment ...

Efficacy and safety of sofosbuvir/velpatasvir alone or in combination with ribavirin in treatment of patients with genotype 3B HCV/HIV infection

Li LIU, Lixian CHANG, Zhiyong CHEN, Junyi LI, Chunyun LIU

2024, 40(2): 271-277. DOI: 10.12449/JCH240209

Abstract(572)

HTML (104)

PDF (800KB)(71)

Abstract:
Objective To investigate the efficacy and safety of sofosbuvir/velpatasvir alone or in combination with ribavirin in Chinese patients with genotype 3B HCV/HIV infection. Methods A total of 299 patients with genotype 3B HCV/HIV infection who attended The Third People’s Hospital of Kunming from Januar...

Preliminary identification of the cloning， expression， and function of Marmota himalayana type I interferon receptor β subunit

Ying TAO, Dongliang YANG, Baoju WANG, Yi LIU, Wenjia GUI, Zhi LI, Hebin FAN

2024, 40(2): 278-283. DOI: 10.12449/JCH240210

Abstract(385)

HTML (147)

PDF (920KB)(30)

Abstract:
Objective To clone the gene of Marmota himalayana type ‍Ⅰ interferon receptor β subunit （mhIFNAR2）， and to perform antibody preparation and functional identification. Methods RT-PCR was used for amplification in the spleen tissue of Marmota himalayana to obtain the sequence， which was cloned to the ...

Fatty Liver Disease

Clinical features and serum lipidomic profile of patients with nonalcoholic fatty liver disease and healthy individuals in the overweight population

Xiaoyan CHEN, Yifu YUAN, Shengnan DU, Qin CAO, Yuanye JIANG

2024, 40(2): 284-291. DOI: 10.12449/JCH240211

Abstract(530)

HTML (188)

PDF (1229KB)(71)

Abstract:
objective To investigate the differences in clinical indices and lipid metabolism between the patients with nonalcoholic fatty liver disease （NAFLD） and healthy individuals in the overweight population. Methods In this study， body mass index （BMI）>23 kg/m² was defined as overweight. A total of 62...

Effect of hyodeoxycholic acid on the activity of steatosis hepatocytes and its mechanism

Yuanyuan WANG, Yan ZOU, Zhaoxia LIU, Xuefeng YANG

2024, 40(2): 292-297. DOI: 10.12449/JCH240212

Abstract(449)

HTML (293)

PDF (1921KB)(48)

Abstract:
Objective To investigate the role and mechanism of hyodeoxycholic acid （HDCA） in the progression of metabolic associated fatty liver disease （MAFLD）， and to provide a new theoretical basis for further clarifying the pathogenesis of MAFLD. Methods L02 hepatocytes were used as experimental cells， and ...

Liver Fibrosis and Liver Cirrhosis

Value of platelet-albumin-bilirubin index combined with AIMS65 score in predicting the short-term prognosis of patients with liver cirrhosis and acute upper gastrointestinal bleeding

Tianjiao DAI, Jing LI

2024, 40(2): 298-305. DOI: 10.12449/JCH240213

Abstract(425)

HTML (195)

PDF (909KB)(59)

Abstract:
Objective To investigate the value of platelet-albumin-bilirubin index （PALBI） combined with AIMS65 score in predicting rebleeding and death within 6 weeks after admission in patients with liver cirrhosis and acute upper gastrointestinal bleeding （AUGIB）. Methods A retrospective study was conducted ...

Clinical application value of a predictive model for the efficacy of third-generation cephalosporin in treatment of community-acquired spontaneous bacterial peritonitis

Longchuan ZHU, Wei WU, Dakai GAN, Wei ZHANG, Yizhen XU, Molong XIONG

2024, 40(2): 306-311. DOI: 10.12449/JCH240214

Abstract(384)

HTML (141)

PDF (922KB)(46)

Abstract:
Objective To investigate the clinical application value of a predictive model for the efficacy of third-generation cephalosporin in the treatment of community-acquired spontaneous bacterial peritonitis （CASBP）. Methods This prospective study was conducted among 50 patients with liver cirrhosis and C...

Protective mechanism of rhubarb decoction against inflammatory damage of brain tissue in rats with mild hepatic encephalopathy： A study based on the PI3K/AKT/mTOR signaling pathway

Guangfa ZHANG, Yingying CAI, Long LIN, Lei FU, Fan YAO, Meng WANG, Rongzhen ZHANG, Yueqiao CHEN, Liangjiang HUANG, Han WANG, Yun SU, Yanmei LAN, Yingyu LE, Dewen MAO, Chun YAO

2024, 40(2): 312-318. DOI: 10.12449/JCH240215

Abstract(389)

HTML (185)

PDF (1982KB)(47)

Abstract:
Objective To investigate the role and possible mechanism of action of rhubarb decoction （RD） retention enema in improving inflammatory damage of brain tissue in a rat model of mild hepatic encephalopathy （MHE）. Methods A total of 60 male Sprague-Dawley rats were divided into blank group （CON group w...

Liver Neoplasm

Proteomic analysis and validation of DNA repair regulation in the process of hepatocellular carcinoma recurrence

Kai CHANG, Yanyan WANG, Zhongyong JIANG, Wei SUN, Chenxia LIU, Wanlin NA, Hongxuan XU, Jing XIE, Yuan LIU, Min CHEN

2024, 40(2): 319-326. DOI: 10.12449/JCH240216

Abstract(441)

HTML (181)

PDF (2144KB)(50)

Abstract:
Objective To investigate the role and mechanism of DNA repair regulation in the process of hepatocellular carcinoma （HCC） recurrence. Methods HCC tissue samples were collected from the patients with recurrence within two years or the patients with a good prognosis after 5 years， and the Tandem Mass ...

Effect of kinesin family member 15 on the proliferation of hepatocellular carcinoma cells and its mechanism of action

Jiannan QIU, Peng WANG, Yin CAO, Zhongxia WANG, Junhua WU, Chunping JIANG

2024, 40(2): 327-334. DOI: 10.12449/JCH240217

Abstract(410)

HTML (175)

PDF (1773KB)(49)

Abstract:
Objective To investigate the effect of kinesin family member 15 （KIF15） on the proliferation of hepatocellular carcinoma （HCC） cells and its mechanism of action. Methods TCGA and GEPIA datasets were analyzed to determine the expression of KIF15 in HCC and its effect on tumor stage and survival. Quan...

Other Liver Disease

Effect of Dendrobium officinale leaf fermentation fluid on a mouse model of alcoholic hepatitis and its mechanism of action

Xingnian ZHOU, Yuhong LIU, Yujie QIN, Quan ZHANG, Mingliang CHENG, Hong LI

2024, 40(2): 335-342. DOI: 10.12449/JCH240218

Abstract(649)

HTML (190)

PDF (2486KB)(65)

Abstract:
Objective To investigate the intervention mechanism of Dendrobium officinale leaf fermentation fluid in mice with alcoholic hepatitis. Methods A total of 70 healthy male C57BL/6J mice， aged 6-8 weeks， were randomly divided into normal group， model group， liquid feed control group， silybin group， and...

Pancreatic Disease

Protective effect of Qingjie Huagong decoction on pancreatic tissue of mice with severe acute pancreatitis by regulating the NOD-like receptor protein 3/Toll-like receptor 4/nuclear factor-kappa B signaling pathway

Minchao FENG, Baijun QIN, Fang LUO, Kai LI, Ning WANG, Guozhong CHEN, Xiping TANG

2024, 40(2): 343-350. DOI: 10.12449/JCH240219

Abstract(492)

HTML (465)

PDF (2916KB)(53)

Abstract:
Objective To investigate the therapeutic effect of Qingjie Huagong decoction （QJHGD） on a mouse model of severe acute pancreatitis （SAP） and the mechanism of action of QJHGD against inflammatory response. Methods A total of 36 male C57BL/6J mice were randomly divided into blank group， model group， W...

New Technology and Therapeutic Strategy

Efficacy of endoscopic retrograde cholangiopancreatography combined with electrohydraulic lithotripsy under the direct view of eyeMax biliary-pancreatic imaging system in treatment of difficult choledocholithiasis

Liying TAO, Hongguang WANG, Qingmei GUO, Lianyu PIAO, Xiang GUO, Libin RUAN, Shizhu LIU, Zhen SUN

2024, 40(2): 351-355. DOI: 10.12449/JCH240220

Abstract(528)

HTML (134)

PDF (807KB)(83)

Abstract:
Objective To investigate the safety and efficacy of endoscopic retrograde cholangiopancreatography （ERCP） combined with electrohydraulic lithotripsy under the direct view of eyeMax biliary-pancreatic imaging system in the treatment of difficult choledocholithiasis. Methods A retrospective analysis w...

Case Report

Niemann-Pick disease type B and heterogeneous manifestations of its liver involvement： A case report

Qiao YANG, Yi SHEN, Yue SHI, Jin WANG, Fangfang LYU

2024, 40(2): 356-360. DOI: 10.12449/JCH240221

Abstract(422)

HTML (136)

PDF (1123KB)(78)

Abstract:
This article reports a case with the chief complaint of “hepatosplenomegaly to be investigated” and a confirmed diagnosis of Niemann-Pick disease type B after various tests， and a literature review was conducted to summarize the heterogeneous manifestations of liver involvement in type B Niemann-Pic...

Recurrent hypertriglyceridemic acute pancreatitis in an adult patient caused by the de novo mutation of p.K327N in the GPD1 gene： A case report

Xiaoyao LI, Jianfeng DUAN, Dacheng WANG, Xiancheng CHEN, Beiyuan ZHANG, Wenkui YU

2024, 40(2): 361-364. DOI: 10.12449/JCH240222

Abstract(449)

HTML (156)

PDF (813KB)(45)

Abstract:
Hypertriglyceridemia （HTG） is the second leading cause of acute pancreatitis in China and can be caused by primary factors， namely gene mutations， which may lead to recurrent hypertriglyceridemic acute pancreatitis （HTG-AP） and difficulties in effective control of triglyceride. This article reports ...

Misdiagnosis of intrapancreatic accessory spleen： A report of two cases

Mengzhe ZHANG, Jie RAO, Zhengle ZHANG

2024, 40(2): 365-368. DOI: 10.12449/JCH240223

Abstract(566)

HTML (218)

PDF (1188KB)(51)

Abstract:
Accessory spleen refers to the spleen tissue that exists outside of the normal spleen， with a similar structure to the main spleen and certain functions. Intrapancreatic accessory spleen （IPAS） completely enveloped by the pancreas has an incidence rate of only 2%， and it is easily misdiagnosed in cl...

Review

Effect of treatment with direct-acting antiviral agents on the prognosis of extrahepatic diseases in patients with hepatitis C

Xiaoyan WANG, Liaoyun ZHANG

2024, 40(2): 369-373. DOI: 10.12449/JCH240224

Abstract(330)

HTML (141)

PDF (571KB)(58)

Abstract:
The prognosis of patients with hepatitis C virus infection depends not only on liver lesions， but also on extrahepatic sequelae. Direct-acting antiviral agents （DAAs）， as the first-line drugs in the treatment of hepatitis C， have helped more and more patients achieve sustained virologic response and...

Association of intestinal microecology with the development and progression of autoimmune hepatitis

Yuyan XIA, Qiongrong ZENG, Fujian LI, Fengyan LI, Qi LI, Lixia TANG, Guo ZHANG

2024, 40(2): 374-379. DOI: 10.12449/JCH240225

Abstract(444)

HTML (127)

PDF (646KB)(73)

Abstract:
Autoimmune hepatitis （AIH） is an autoimmune disease characterized by chronic liver inflammation， with a gradually increasing incidence rate， and its social and medical burdens cannot be neglected. Intestinal microecology is becoming a research hotspot in the field of autoimmune disease. In recent ye...

Current research status of Gd-EOB-DTPA-enhanced MRI in evaluating liver reserve function in residual liver tissue after liver tumor surgery

Yanhong YE, Lijian LU

2024, 40(2): 380-385. DOI: 10.12449/JCH240226

Abstract(504)

HTML (201)

PDF (630KB)(49)

Abstract:
As a non-invasive， simple， and reproducible examination， Gd-EOB-DTPA-enhanced magnetic resonance imaging （MRI） has an important application value in evaluating liver reserve function. Currently in clinical practice， Gd-EOB-DTPA-enhanced MRI is mainly used to measure liver parenchymal signal intensit...

Research advances in second-line therapies for hepatocellular carcinoma after resistance to targeted therapy combined with immunotherapy

Tianqi ZHANG, Yuzhe CAO, Mengxuan ZUO, Yangkui GU

2024, 40(2): 386-390. DOI: 10.12449/JCH240227

Abstract(1125)

HTML (336)

PDF (552KB)(145)

Abstract:
In recent years， clinical studies on targeted therapy and immunotherapy for advanced hepatocellular carcinoma used alone or in combination have provided abundant evidence on efficacy and safety for the selection of first-line therapies. However， no consensus has been reached on the selection of seco...

Application of Mendelian randomization in liver cancer

Lingwei LI, Junjie QIN, Yunlong JIA, Hao LYU

2024, 40(2): 391-396. DOI: 10.12449/JCH240228

Abstract(1090)

HTML (640)

PDF (609KB)(158)

Abstract:
In recent years， the research method of Mendelian randomization based on genome-wide association studies has been widely used for etiological exploration in the medical field， which can effectively overcome the confounding biases and interference of reverse causalities in traditional observational r...

Role of NOD-like receptor protein 3 inflammasome in the development and progression of hepatocellular carcinoma

Xuehai YU, Bendong CHEN, Yimin LIU, Yongxin MA, Xusheng ZHANG, Hongcai ZHOU, Haiyan MA

2024, 40(2): 397-401. DOI: 10.12449/JCH240229

Abstract(845)

HTML (193)

PDF (942KB)(58)

Abstract:
In recent years， NOD-like receptor protein 3 （NLRP3） inflammasome in tumors has become a research hotspot， especially in melanoma， colorectal cancer， lung cancer， and breast cancer， and more and more evidence has shown that inflammation plays a role in the development， progression， angiogenesis， and...

Pathogenesis of liver injury caused by antiviral drugs for coronavirus disease 2019

Xue ZENG, Fuqing LI, Qingqing LI, Hong WANG

2024, 40(2): 402-407. DOI: 10.12449/JCH240230

Abstract(549)

HTML (255)

PDF (669KB)(52)

Abstract:
Drug-induced liver injury is caused by the drug itself and/or its metabolites during drug use or occurs due to hypersensitivity or reduced tolerance to the drug in a particular body type. In the last three years of the diagnosis and treatment of coronavirus disease 2019 （COVID-19）， antiviral drugs h...

Clinical significance of benign liver function abnormality

Xu HAN, Jia LI, Qingfang XIONG, Yongfeng YANG

2024, 40(2): 408-412. DOI: 10.12449/JCH240231

Abstract(766)

HTML (381)

PDF (587KB)(195)

Abstract:
Biochemical liver function tests are important methods to determine liver function in clinical practice， but abnormal liver biochemical parameters are not completely equivalent to liver damage. Some genetic and immune factors can also cause abnormal liver biochemical parameters， but with good progno...

Role of mitophagy in the development and progression of liver-related diseases

Meng PAN, Xiaoyan SHI

2024, 40(2): 413-418. DOI: 10.12449/JCH240232

Abstract(736)

HTML (478)

PDF (762KB)(69)

Abstract:
Mitophagy is a type of selective autophagy during which cells specifically remove damaged mitochondria in response to nutrient deficiency or external stimulation and thus maintain the integrity of mitochondrial function and cellular homeostasis. In recent years， a large number of studies have shown ...

Association between deacetylase Sirtuins and radiation-induced liver disease

Yekai ZONG, Jiangkai LIU

2024, 40(2): 419-425. DOI: 10.12449/JCH240233

Abstract(465)

HTML (150)

PDF (693KB)(35)

Abstract:
Radiation-induced liver disease （RILD）， also known as radiation hepatitis， is subacute liver injury induced by radiation. As the focus of senescence-related studies， the deacetylase family Sirtuins （SIRTs） have the molecular functions including DNA repair and chromatin regulation， which makes SIRTs ...

Advances in molecular-targeted therapy for unresectable pancreatic cancer

Run HU, Junen LI, Pei YAO, Renjie GUI, Huaxin DUAN

2024, 40(2): 426-432. DOI: 10.12449/JCH240234

Abstract(1120)

HTML (796)

PDF (672KB)(153)

Abstract:
Pancreatic cancer is one of the most prevalent malignant tumors of the digestive system， and its incidence and mortality rates are increasing year by year. Most patients with pancreatic cancer are unable to receive surgery due to the advanced stage. Although chemotherapy regimens based on gemcitabin...

Introduction of High - quality Articles in Foreign Journals

Journal of Hepatology｜Metabolic biomarkers significantly enhance the prediction of HBV-related ACLF occurrence and outcomes

2024, 40(2): 257-257. DOI: 10.12449/JCH2402.gwqkjpwzjj1

Abstract(274)

HTML (125)

PDF (1217KB)(37)

Abstract:

Hepatology International｜Clinic-radiomics model using liver magnetic resonance imaging helps predict chronicity of drug-induced liver injury

2024, 40(2): 270-270. DOI: 10.12449/JCH2402.gwqkjpwzjj2

Abstract(207)

HTML (112)

PDF (848KB)(37)