中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 8
Aug.  2014
Turn off MathJax
Article Contents

Pathogenetic mechanism of microcirculatory disturbance and treatment advances in acute pancreatitis

DOI: 10.3969/j.issn.1001-5256.2014.08.033
Research funding:

 

  • Received Date: 2014-07-14
  • Published Date: 2014-08-20
  • In recent years, there has been increasing evidence that microcirculatory disturbance, including vasoconstriction, shunting, inadequate perfusion, increased blood viscosity, and coagulation, is closely associated with the pathogenesis of acute pancreatitis (AP) .These processes may be exacerbated by ischaemia- reperfusion injury and the generation of oxygen radicals.The anatomical features of pancreatic microcirculation, the pathophysiological mechanism of pancreatic microcirculation disturbance and related inflammatory mediators, and progress in the treatment of microcirculatory disturbance in AP are reviewed.It is suggested that the pancreatic and systemic microcirculation may play a key role in the development and progression of AP.

     

  • loading
  • [1]SAND J, NORDBACK I.Acute pancreatitis:risk of recurrence and late consequences of the disease[J].Nat Rev Gastroenterol Hepatol, 2009, 6 (8) :470-477.
    [2]WHITCOMB DC.Clinical practice.Acute pancreatitis[J].N Engl J Med, 2006, 354 (20) :2142-2150.
    [3]YADAV D, LOWENFELS AB.The epidemiology of pancreatitis and pancreatic cancer[J].Gastroenterology, 2013, 144 (6) :1252-1261.
    [4]MITCHELL RM, BYRNE MF, BAILLIE J.Pancreatitis[J].Lancet, 2003, 361 (9367) :1447-1455.
    [5]PLUSCZYK T, WITZEL B, MENGER MD, et al.ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury[J].Am J Physiol Gastrointest Liver Physiol, 2003, 285 (1) :g145-g153.
    [6]TAKEDA K, MIKAMI Y, FUKUYAMA S, et al.Pancreatic ischemia associated with vasospasm in the early phase of human acute necrotizing pancreatitis[J].Pancreas, 2005, 30 (1) :40-49.
    [7]ZHANG XP, LI ZJ, ZHANG J.Inflammatory mediators and microcirculatory disturbance in acute pancreatitis[J].Hepatobiliary Pancreat Dis Int, 2009, 8 (4) :351-357.
    [8]KOH YY, JEON WK, CHO YK, et al.The effect of intestinal permeability and endotoxemia on the prognosis of acute pancreatitis[J].Gut Liver, 2012, 6 (4) :505-511.
    [9]DABROWSKI A, OSADA J, DABROWSKA MI, et al.Increased expression of the intercellular adhesion molecule-1 (ICAM-1) on peripheral blood neutrophils in acute pancreatitis[J].Adv Med Sci, 2014, 59 (1) :102-107.
    [10]ROUDEBUSH WE, WILD MD, MAGUIRE EH.Expression of the platelet-activating factor receptor in human spermatozoa:differences in messenger ribonucleic acid content and protein distribution between normal and abnormal spermatozoa[J].Fertil Steril, 2000, 73 (5) :967-971.
    [11]ZHAO YF, ZHAI WL, ZHANG SJ, et al.Protection effect of triptolide to liver injury in rats with severe acute pancreatitis[J].Hepatobiliary Pancreat Dis Int, 2005, 4 (4) :604-608.
    [12]POORAN N, INDARAM A, SINGH P, et al.Cytokines (IL-6, IL-8, TNF) :early and reliable predictors of severe acute pancreatitis[J].J Clin Gastroenterol, 2003, 37 (3) :263-266.
    [13]KIHARA Y, YOSHIKAWA H, HONDA H, et al.Natural disruption of group 2 phospholipase A2 gene protects against choline-deficient ethionine-supplemented diet-induced acute pancreatitis and lung injury[J].Pancreas, 2005, 31 (1) :48-53.
    [14]DIMAGNO MJ, WILLIAMS JA, HAO Y, et al.Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice[J].Am J Physiol Gastrointest Liver Physiol, 2004, 287 (1) :g80-g87.
    [15]ARMSTRONG JA, CASH N, SOARES PM, et al.Oxidative stress in acute pancreatitis:lost in translation?[J].Free Radic Res, 2013, 47 (11) :917-933.
    [16]GERASIMENKO JV, GERASIMENKO OV, PETERSEN OH.The role of Ca2+in the pathophysiology of pancreatitis[J].J Physiol, 2014, 592 (Pt 2) :269-280.
    [17]ZAHEER A, SINGH VK, QURESHI RO, et al.The revised Atlanta classification for acute pancreatitis:updates in imaging terminology and guidelines[J].Abdom Imaging, 2013, 38 (1) :125-136.
    [18]LENG F, YANG L, CHANG ZG, et al.Classification for acute pancreatitis-2012:revision of the Atlanta classification and definitions by international consensus[J].J Clin Hepatol, 2013, 29 (4) :Ⅰ-Ⅶ. (in Chinese) 冷芳, 杨力, 常志刚, 等.急性胰腺炎分类——2012:亚特兰大分类和定义修订的国际共识[J].临床肝胆病杂志, 2013, 29 (4) :Ⅰ-Ⅶ.
    [19]KOKSOY FN, YANKOL Y, SEN OE, et al.Preventive effects of enoxaparin and hesperidin in cerulein-induced acute pancreatitis in rats[J].Turk J Gastroenterol, 2013, 24 (6) :495-501.
    [20]LI S, CHEN X, WU T, et al.Role of heparin on serum VEGF levels and local VEGF contents in reducing the severity of experimental severe acute pancreatitis in rats[J].Scand J Gastroenterol, 2012, 47 (2) :237-244.
    [21]QIU F, LU XS, HUANG YK.Protective effect of low-molecularweight heparin on pancreatic encephalopathy in severe acute pancreatic rats[J].Inflamm Res, 2012, 61 (11) :1203-1209.
    [22]UHLMANN D, LAUER H, SERR F, et al.Pathophysiological role of platelets in acute experimental pancreatitis:influence of endothelin A receptor blockade[J].Cell Tissue Res, 2007, 327 (3) :485-492.
    [23]MARTIGNONI ME, CEYHAN GO, AYUNI E, et al.Endothelin receptor antagonists are not beneficial in the therapy of acute experimental pancreatitis[J].Langenbecks Arch Surg, 2004, 389 (3) :184-192.
    [24]MANN O, TIEFENBACHER WJ, KAIFI J, et al.Effect of plateletactivating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity[J].Pancreas, 2009, 38 (1) :58-64.
    [25]HIRANO T, HIRANO K.Thromboxane A2 receptor antagonist prevents pancreatic microvascular leakage in rats with caerulein-induced acute pancreatitis[J].Int J Surg Investig, 1999, 1 (3) :203-210.
    [26]DOBOSZ M, HAC S, MIONSKOWSKA L, et al.Organ microcirculatory disturbances in experimental acute pancreatitis.A role of nitric oxide[J].Physiol Res, 2005, 54 (4) :363-368.
    [27]LEINDLER L, MORSCHL E, LASZLO F, et al.Importance of cytokines, nitric oxide, and apoptosis in the pathological process of necrotizing pancreatitis in rats[J].Pancreas, 2004, 29 (2) :157-161.
    [28]BLOECHLE C, KUSTERER K, KUEHN RM, et al.Inhibition of bradykinin B2 receptor preserves microcirculation in experimental pancreatitis in rats[J].Am J Physiol, 1998, 274 (1 Pt 1) :g42-g51.
    [29]GRIESBACHER T, RAINER I, TIRAN B, et al.Kallikrein inhibitors limit kinin B (2) antagonist-induced progression of oedematous to haemorrhagic pancreatitis in rats[J].Br J Pharmacol, 2008, 155 (6) :865-874.
    [30]KECK T, WERNER J, BANAFSCHE R, et al.Oxygen radicals promote ICAM-1 expression and microcirculatory disturbances in experimental acute pancreatitis[J].Pancreatology, 2003, 3 (2) :156-163.
    [31]ITO Y, LUGEA A, PANDOL SJ, et al.Substance P mediates cerulein-induced pancreatic microcirculatory dysfunction in mice[J].Pancreas, 2007, 34 (1) :138-143.
    [32]ZHANG XP, SHI Y, ZHANG L.Progress in the study of therapeutic effects of traditional Chinese medicine and extracts in treating severe acute pancreatitis[J].JOP, 2007, 8 (6) :704-714.
    [33]CAI Z, KNORR D, SMETANSKA I.Enhanced anthocyanins and resveratrol production in Vitis vinifera cell suspension culture by indanoyl-isoleucine, N-linolenoyl-L-glutamine and insect saliva[J].Enzyme Microb Technol, 2012, 50 (1) :29-34.
    [34]PIOTROWSKA H, KUCINSKA M, MURIAS M.Biological activity of piceatannol:leaving the shadow of resveratrol[J].Mutat Res, 2012, 750 (1) :60-82.
    [35]KARALIS F, SOUBASI V, GEORGIOU T, et al.Resveratrol ameliorates hypoxia/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain[J].Brain Res, 2011, 1425:98-110.
    [36]SHA H, MA Q, JHA RK, et al.Resveratrol suppresses microcirculatory disturbance in a rat model of severe acute pancreatitis[J].Cell Biochem Biophys, 2013, 67 (3) :1059-1065.
    [37]ANDERSSON E, AXELSSON J, PEDERSEN LC, et al.Treatment with anti-factor VIIa in acute pancreatitis in rats:blocking both coagulation and inflammation?[J].Scand J Gastroenterol, 2007, 42 (6) :765-770.
    [38]DU BQ, YANG YM, CHEN YH, et al.N-acetylcysteine improves pancreatic microcirculation and alleviates the severity of acute necrotizing pancreatitis[J].Gut Liver, 2013, 7 (3) :357-362.
    [39]NIKFARJAM M, CUTHBERTSON CM, MALCONTENTI-WILSON C, et al.Hyperbaric oxygen therapy reduces severity and improves survival in severe acute pancreatitis[J].J Gastrointest Surg, 2007, 11 (8) :1008-1015.
    [40]ONUR E, PAKSOY M, BACA B, et al.Hyperbaric oxygen and Nacetylcysteine treatment in L-arginine-induced acute pancreatitis in rats[J].J Invest Surg, 2012, 5 (1) :20-28.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2948) PDF downloads(596) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return