中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R

Research advances in liver injury induced by programmed death protein-1 inhibitors

DOI: 10.3969/j.issn.1001-5256.2019.09.051
  • Received Date: 2019-03-28
  • Published Date: 2019-09-20
  • With the application of programmed cell death-1 ( PD-1) inhibitors in tumor treatment, related side effects and immune-related adverse events ( irAEs) are observed in the whole body; however, there are few studies on liver injury in irAEs. This article elaborates on the features of liver injury induced by PD-1 inhibitors from the aspects of molecular mechanism, disease grade, incidence rate, onset time, serology, histology, imaging, and biomarkers and related treatment methods, so as to provide a comprehensive understanding of liver injury in irAEs. It is believed that although there is a low incidence rate of liver injury caused by PD-1 inhibitors, high-grade liver injury has a high level of risk. Such liver injury should be taken seriously by the medical staff, and early identification and proper treatment should be performed.

     

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