Role of the Hippo signaling pathway in the development and progression of primary liver cancer

Hong YingHui; Wang Chun; Ye MingLiang; Luo Jie; Liu JiaLiang; Ren Chao; Lan SiYu; Zhao Qiu; Chang Ying

doi:10.3969/j.issn.1001-5256.2020.05.050

Volume 36 Issue 5

May 2020

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Article Navigation > Journal of Clinical Hepatology > 2020 > 36(5): 1171-1174

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Role of the Hippo signaling pathway in the development and progression of primary liver cancer

DOI: 10.3969/j.issn.1001-5256.2020.05.050

Hubei Key Laboratory of Intestinal and Colorectal Diseases, Hubei Clinical Center of Intestinal and Colorectal Diseases, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

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Published Date: 2020-05-20

Abstract

Abstract

The incidence rate of primary liver cancer continues to increase around the world, with a younger age of onset and poorer prognosis. As the most classic regulator of cell polarity and density, mechanical signal transduction, cell proliferation, and organ development, the Hippo pathway can promote the development and progression of various cancers including primary liver cancer. YAP, a classic nuclear effector of the Hippo pathway, is significantly upregulated in primary liver cancer and promotes the development of drug resistance. This article aims to investigate the association of the dysregulation of the Hippo signaling pathway with the development and progression of primary liver cancer and analyzes the mechanism of action of the Hippo signaling pathway in the drug resistance of primary liver cancer as an early event of the development of primary liver cancer, which is of great significance for exploring new treatment strategies for primary liver cancer.
- liver neoplasms,
- signal transduction,
- Hippo pathway

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References(40)

References

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沈阳化工大学材料科学与工程学院沈阳 110142

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Role of the Hippo signaling pathway in the development and progression of primary liver cancer

DOI: 10.3969/j.issn.1001-5256.2020.05.050