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Volume 37 Issue 5
May  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(5): 1189-1192

Research advances in anti-hepatitis B virus therapy targeting covalently closed circular DNA

DOI: 10.3969/j.issn.1001-5256.2021.05.044

  • Department of Hepatology, The First Hospital of Jilin University, Changchun 130000, China

  • Received Date: 2020-10-12
  • Accepted Date: 2020-11-23
  • Published Date: 2021-05-20
    Abstract
  • The incurable chronic infection caused by hepatitis B virus (HBV) is the major health burden worldwide. Covalently closed circular DNA (cccDNA) exists in the nucleus of infected cells as a stable minichromosome, and when a new therapy realizes inactivation or eliminates persistent cccDNA in infected hepatocytes, the natural process of chronic infection and long-term antiviral therapy will no longer exist. This article introduces the methods targeting cccDNA, such as gene editing and epigenetic modification, so as to achieve the complete cure of HBV infection.

     

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    宰文静, 陈捷亮, 袁正宏. HBV cccDNA转录代谢调控机制及沉默清除策略[J]. 临床肝胆病杂志, 2020, 36(5): 983-988. DOI: 10.3969/j.issn.1001-5256.2020.05.006.
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