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ISSN 2097-3497 (Online)
CN 22-1108/R
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2023 No.3
Theme Issue: Liver pathology and precision diagnosis and treatment of liver diseases
Executive Chief Editor: YANG Yongfeng  
Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine & Nanjing Second Hospital
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Editorial
Liver pathology from the perspective of clinicians
Yongfeng YANG
2023, 39(3): 489-490. DOI: 10.3969/j.issn.1001-5256.2023.03.001
Abstract(789) HTML (415) PDF (1786KB)(196)
Abstract:
Liver histopathology plays an important role in the grading and staging of liver diseases and the etiological evaluation of unexplained liver diseases. Clinicians should fully understand the indications and contraindications for liver biopsy, the pathological features of liver diseases, the position...
Discussions by Experts
Diagnosis of nonalcoholic fatty liver disease: The importance of pathology
Aiping TIAN, Yongfeng YANG
2023, 39(3): 491-497. DOI: 10.3969/j.issn.1001-5256.2023.03.002
Abstract(1519) HTML (1191) PDF (3621KB)(492)
Abstract:
Histopathological evaluation based on liver biopsy is required to make a confirmed diagnosis of nonalcoholic fatty liver disease, differentiate nonalcoholic fatty liver (NAFL) from nonalcoholic steatohepatitis (NASH), and perform the grading and scoring of disease severity, while hematological and r...
Thinking of the pathological diagnosis of unexplained liver cirrhosis
Yu ZHANG, Yongfeng YANG
2023, 39(3): 498-503. DOI: 10.3969/j.issn.1001-5256.2023.03.003
Abstract(1272) HTML (394) PDF (1771KB)(310)
Abstract:
Liver cirrhosis is the final stage of various chronic liver diseases, and the common etiologies of liver cirrhosis include chronic viral hepatitis, nonalcoholic fatty liver disease, autoimmune liver diseases, and inherited metabolic liver disease. An accurate etiological diagnosis is an important pr...
Diagnosis and treatment of autoimmune hepatitis: The indispensable role of pathology
Li WANG, Yongfeng YANG
2023, 39(3): 504-510. DOI: 10.3969/j.issn.1001-5256.2023.03.004
Abstract(866) HTML (200) PDF (2286KB)(217)
Abstract:
Autoimmune hepatitis has become the main type of non-infectious hepatitis in China. This article summarizes its characteristic manifestations and the current status of diagnosis and treatment and points out that pathological histology plays an indispensable role in the diagnosis and treatment of aut...
Diagnosis and treatment of primary biliary cholangitis: Is pathology necessary?
Hongli LIU, Yongfeng YANG
2023, 39(3): 511-516. DOI: 10.3969/j.issn.1001-5256.2023.03.005
Abstract(827) HTML (180) PDF (2564KB)(211)
Abstract:
Primary biliary cholangitis (PBC) is a chronic intrahepatic cholestatic disease. This article summarizes and reviews the histopathological features of PBC and the role of pathological examination in the diagnosis and treatment of PBC, as well as the role of pathology in staging and prognosis, the di...
Differential pathological diagnosis of liver tissue with normal appearance
Mengmeng ZHANG, Yao MENG, Xinyan ZHAO
2023, 39(3): 517-522. DOI: 10.3969/j.issn.1001-5256.2023.03.006
Abstract(714) HTML (1608) PDF (5545KB)(299)
Abstract:
Liver biopsy is a key method for clarifying the diagnosis of liver diseases and has an important value in determining disease severity, deciding treatment timing, and predicting treatment response and prognosis. By recognizing the pattern of liver pathological injury, pathologists evaluate the natur...
Academic Contention
Can green tea extract cause specific liver injury?——Discussion of the latest US guidelines on drug-induced liver injury
Yunjuan GAO, Xu ZHAO, Jingxiao ZHU, Zhaofang BAI, Jiabo WANG, Xiaohe XIAO
2023, 39(3): 523-526. DOI: 10.3969/j.issn.1001-5256.2023.03.007
Abstract(627) HTML (160) PDF (1739KB)(108)
Abstract:
In recent years, the potential hepatotoxicity of green tea extract (GTE) has attracted more and more attention. With reference to the current studies on liver injury caused by GTE and the latest drug hepatotoxicity classification, this article systematically elaborates on the objectivity and causal ...
Original Article_Viral Hepatitis
Efficacy and safety of the 12-week sofosbuvir-coblopasvir regimen in treatment of chronic hepatitis C
Wei ZHANG, Song ZHAI, Hong DU, Fuchun JING, Limei WANG, Ye ZHANG, Bibo KANG, Jiuping WANG, Shuangsuo DANG, Jianqi LIAN, Hong JIANG
2023, 39(3): 539-545. DOI: 10.3969/j.issn.1001-5256.2023.03.009
Abstract(870) HTML (195) PDF (2213KB)(121)
Abstract:
Objective To investigate the efficacy and safety of the 12-week regimen with sofosbuvir and coblopasvir hydrochloride in the treatment of chronic hepatitis C (CHC) in northwest China. Methods This study enrolled 101 patients with CHC of any genotype who received sofosbuvir (400 mg) combined with cob...
Original Article_Fatty Liver Disease
Value of triglyceride-glucose index combined with obesity index in predicting nonalcoholic fatty liver disease in individuals with obstructive sleep apnea
Rong JIANG, Yongxia LI
2023, 39(3): 546-551. DOI: 10.3969/j.issn.1001-5256.2023.03.010
Abstract(636) HTML (139) PDF (1893KB)(93)
Abstract:
Objective To investigate the value of triglyceride-glucose index (TyG), TyG combined with body mass index (BMI), and TyG combined with waist circumference (WC) in predicting nonalcoholic fatty liver disease (NAFLD) in patients with obstructive sleep apnea (OSA). Methods A retrospective analysis was ...
Association between the rs1800591 variation of the microsomal triglyceride transfer protein gene and the risk of nonalcoholic fatty liver disease in the elderly population
Jinhan ZHAO, Jing ZHANG, Yang ZHANG, Xiaoyi XU, Yusong GOU, Hangfei XU, Yan WAN, Jian WU
2023, 39(3): 552-561. DOI: 10.3969/j.issn.1001-5256.2023.03.011
Abstract(483) HTML (171) PDF (1938KB)(72)
Abstract:
Objective To investigate the association between the polymorphism of the microsomal triglyceride transport protein (MTTP) gene at rs1800591 locus and the risk of nonalcoholic fatty liver disease (NAFLD) in the elderly population. Methods The clinical cohort of this study was established in Menkuang ...
Changes in the frequency, phenotype, and function of mucosal-associated invariant T lymphocytes in peripheral blood of children with metabolic associated fatty liver disease
Tao JIANG, Wenxian OUYANG, Yanfang TAN, Zhen KANG, Shuangjie LI
2023, 39(3): 562-566. DOI: 10.3969/j.issn.1001-5256.2023.03.012
Abstract(498) HTML (156) PDF (1753KB)(66)
Abstract:
Objective To investigate the change in mucosal-associated invariant T (MAIT) lymphocytes in peripheral blood of children with metabolic associated fatty liver disease (MAFLD) and its clinical significance. Methods A total of 18 children with MAFLD who attended Hunan Children's Hospital from March to...
Original Article_Autoimmune Liver Disease
Association between primary sclerosing cholangitis and the risk of colorectal cancer: A two-sample Mendelian randomization study
Zhenqi LI, Ning DU, Hongyang He
2023, 39(3): 567-572. DOI: 10.3969/j.issn.1001-5256.2023.03.013
Abstract(1218) HTML (562) PDF (2338KB)(184)
Abstract:
Objective To investigate the association between primary sclerosing cholangitis (PSC) and colorectal cancer (CRC) by using two-sample Mendelian randomization (TSMR). Methods The single nucleotide polymorphism (SNP) data associated with PSC and CRC were obtained from Finland Biobank and UK Biobank, r...
Original Article_Liver Fibrosis and Liver Cirrhosis
Value of liver-muscle signal intensity and serum markers in diagnosis of chronic hepatitis B liver fibrosis
Ya WEN, Zhaoyu QU, Jingnan LU, Weiling YIN, Xiaoqi HUANG
2023, 39(3): 573-579. DOI: 10.3969/j.issn.1001-5256.2023.03.014
Abstract(458) HTML (162) PDF (2480KB)(85)
Abstract:
Objective To investigate the value of liver/muscle ratio (LMR) on susceptibility-weighted imaging (SWI) and serum markers in the diagnosis of the severity of chronic hepatitis B liver fibrosis after grouping based on alanine aminotransferase (ALT) level. Methods A retrospective analysis was performe...
Association of P-I-R classification and Laennec grading with histology and prognosis after antiviral therapy in patients with hepatitis B cirrhosis
Caihong LYU, Zheng SONG, Jing LUO, Xiujuan CHANG, Yongping YANG
2023, 39(3): 580-589. DOI: 10.3969/j.issn.1001-5256.2023.03.015
Abstract(533) HTML (403) PDF (3408KB)(75)
Abstract:
Objective To investigate the role of P-I-R classification and Laennec grading in evaluating histological changes in patients with hepatitis B cirrhosis after receiving antiviral therapy, as well as the association of these two evaluation systems with clinical prognosis. Methods A total of 218 patien...
Value of different scoring models in predicting the survival of patients with liver cirrhosis after transjugular intrahepatic portosystemic shunt
Yuyi LIU, Zhiyong MU, Lu HU, Jun WANG, Wei XIONG, Hong HU, Aimin LIU, Xuan AN, Yuqiang XU, Haodong YU, Jinneng WANG, Liangzhi WEN, Dongfeng CHEN
2023, 39(3): 590-598. DOI: 10.3969/j.issn.1001-5256.2023.03.016
Abstract(507) HTML (180) PDF (3395KB)(117)
Abstract:
Objective To compare the value of Child-Pugh score, Model for End-Stage Liver Disease (MELD) score, MELD combined with serum sodium concentration (MELD-Na) score, CLIF Consortium Acute Decompensation (CLIF-C AD) score, and Freiburg index of post-transjugular intrahepatic portosystemic shunt (TIPS) s...
Original Article_Liver Neoplasm
Value of a scoring system based on the serum levels of alpha-fetoprotein and alkaline phosphatase in predicting the prognosis of patients with resectable hepatocellular carcinoma
Jing LU, Yamin ZHANG, Hua LI, Yan MIAO
2023, 39(3): 599-605. DOI: 10.3969/j.issn.1001-5256.2023.03.017
Abstract(574) HTML (281) PDF (2441KB)(111)
Abstract:
Objective To establish a scoring system based on the preoperative serum levels of alpha-fetoprotein (AFP) and alkaline phosphatase (ALP), and to investigate its value in predicting the prognosis of patients with resectable hepatocellular carcinoma (HCC). Methods A retrospective analysis was performe...
Original Article_Other Liver Disease
Value of total bilirubin rebound rate and total bilirubin clearance rate in evaluating the prognosis of severe drug-induced liver injury after artificial liver support therapy
Ying LIU, Ping ZHU, Jing LIANG, Huiling XIANG
2023, 39(3): 606-612. DOI: 10.3969/j.issn.1001-5256.2023.03.018
Abstract(902) HTML (395) PDF (2448KB)(99)
Abstract:
Objective To investigate the value of total bilirubin rebound rate (TBRR), total bilirubin clearance rate (TBCR), and TBCR after 1 week of treatment (ΔTBCR) in evaluating the short-term prognosis of patients with severe drug-induced liver injury (DILI) after artificial liver support therapy. Methods...
Value of a risk assessment model in predicting venous thromboembolism in patients with liver failure after artificial liver support therapy
Sufang LU, Rui HUANG, Hongli ZHAO, Dandan WANG, Yuzhen DING, Hong ZHOU
2023, 39(3): 613-619. DOI: 10.3969/j.issn.1001-5256.2023.03.019
Abstract(489) HTML (142) PDF (1949KB)(92)
Abstract:
Objective To investigate the value of a risk assessment model in predicting venous thromboembolism (VTE) in patients with liver failure after artificial liver support therapy. Methods A retrospective analysis was performed for the clinical data of 124 patients with liver failure who received artifi...
Brief Report
Clinical features of patients with portal hypertension due to Abernethy malformation: An analysis of 5 cases
Tingting BAI, Qin LI, Liangzhi WEN, Yanmei ZHANG, Yanling WEI, Bin WANG, Dongfeng CHEN, Hanyang XING
2023, 39(3): 620-625. DOI: 10.3969/j.issn.1001-5256.2023.03.020
Abstract(380) HTML (204) PDF (3579KB)(101)
Abstract:
Case Report
Transient aplastic anemia associated with acute hepatitis B: A case report
Yu ZHANG, Yu TIAN, Meili DONG, Ruihua ZHANG, Yang WANG, Xiaoyu WEN
2023, 39(3): 626-629. DOI: 10.3969/j.issn.1001-5256.2023.03.021
Abstract(469) HTML (156) PDF (2880KB)(105)
Abstract:
A case of Danon's disease with recurrent abnormal liver function
Leilei PU, Rong ZHU
2023, 39(3): 630-633. DOI: 10.3969/j.issn.1001-5256.2023.03.022
Abstract(585) HTML (282) PDF (2430KB)(123)
Abstract:
Streptococcus constellatus liver abscess caused by fish bone: A case report
Jiajia LI, He WANG, Jidong GUO, Chao WANG, Wenjie QI
2023, 39(3): 634-636. DOI: 10.3969/j.issn.1001-5256.2023.03.023
Abstract(754) HTML (232) PDF (2208KB)(105)
Abstract:
Endoscopic sequential ligation for treatment of esophageal and gastric varices with duodenal varices: A case report
Hao WEN, Zhaohui HE, Tong JIANG, Guoqing SHI
2023, 39(3): 637-639. DOI: 10.3969/j.issn.1001-5256.2023.03.024
Abstract(510) HTML (185) PDF (2676KB)(89)
Abstract:
Massive hepatic hemangioma with diffuse arterioportal fistula: A case report
Bangjian ZHOU, Jun YANG, Yu YIN, Xiaoli ZHU, Caifang NI, Wansheng WANG
2023, 39(3): 640-643. DOI: 10.3969/j.issn.1001-5256.2023.03.025
Abstract(608) HTML (157) PDF (3500KB)(91)
Abstract:
Review
Role of new serological markers in evaluating the progression of liver disease in patients with chronic HBV infection and normal aminotransferases
Yuan WANG, Huaie LIU, Jie DING, Qingqing WANG, Aili WANG, Hui SUN, Hui CAO
2023, 39(3): 644-650. DOI: 10.3969/j.issn.1001-5256.2023.03.026
Abstract(660) HTML (227) PDF (1777KB)(155)
Abstract:
Antiviral therapy is the basic treatment method for improving prognosis recommended in the management guidelines of chronic hepatitis B in China and globally. For patients with chronic HBV infection and normal transaminases, it is difficult in clinical practice to accurately evaluate the progression...
Research advances in hepatitis B virus-associated glomerulonephritis
Zhaoxia LI, Nan LI, Guijie XIN
2023, 39(3): 651-656. DOI: 10.3969/j.issn.1001-5256.2023.03.027
Abstract(846) HTML (209) PDF (2004KB)(191)
Abstract:
There is are large number of patients with chronic hepatitis B virus (HBV) infection. HBV not only damages the liver, but also involves the kidney. Hepatitis B virus-associated glomerulonephritis (HBV-GN) is secondary glomerulonephritis caused by HBV infection, and it is one of the most common extra...
Role of serum Golgi protein 73 in nonalcoholic fatty liver disease
Hang ZHANG, Jinchun LIU
2023, 39(3): 657-662. DOI: 10.3969/j.issn.1001-5256.2023.03.028
Abstract(682) HTML (205) PDF (1767KB)(102)
Abstract:
Golgi protein 73 (GP73) is a Golgi transmembrane protein that can be released into blood by cleavage. An increasing number of studies have shown that the increase in serum GP73 is closely associated with the development and progression of nonalcoholic fatty liver disease (NAFLD) and serum GP73 is ex...
Research advances in effective constituents of traditional Chinese medicine in intervention of autoimmune hepatitis-related signaling pathways
Junyu HAO, Guangwei LIU, Lu XIE, Wenyan FAN, Hongxiu CHEN
2023, 39(3): 663-670. DOI: 10.3969/j.issn.1001-5256.2023.03.029
Abstract(815) HTML (201) PDF (2445KB)(117)
Abstract:
As a chronic liver inflammation disease caused by the lack of immune tolerance, autoimmune hepatitis is regulated by various signaling pathways, such as the NF-κB/NLRP3 pathway, the SIRT1/Nrf2/HO-1 pathway, the Hippo-YAP/TAZ pathway, the JAK/STAT pathway, the PI3K/Akt pathway, and the TRAF6/JNK path...
Research advances in the association between sarcopenia and hepatic encephalopathy in patients with liver cirrhosis
Yijing ZHU, Wei LI, Shousong ZHAO
2023, 39(3): 671-676. DOI: 10.3969/j.issn.1001-5256.2023.03.030
Abstract(653) HTML (185) PDF (1759KB)(114)
Abstract:
Sarcopenia is one of the manifestations of malnutrition in patients with liver cirrhosis. Most studies have shown that sarcopenia is associated with overt hepatic encephalopathy (OHE), leading to an increased risk of events such as reduced quality of life, poor clinical prognosis, and even death in ...
Application of near-infrared fluorescence imaging in hepatectomy of hepatocellular carcinoma
Yanheng DUAN, Jiaze AN
2023, 39(3): 677-683. DOI: 10.3969/j.issn.1001-5256.2023.03.031
Abstract(514) HTML (160) PDF (1773KB)(98)
Abstract:
Multimodality therapy based on surgery is the main treatment method for hepatocellular carcinoma (HCC), and hepatectomy requires the removal of primary tumor and the preservation of normal liver tissue to the maximum extent. However in clinical surgery, it is difficult to accurately identify tumor t...
Influence of the interaction between tumor microenvironment and liver cancer stem cells on the development and progression of hepatocellular carcinoma
Yanxin TIAN, Na LI, Lei GAO, Jia WU, Ying ZHU
2023, 39(3): 684-692. DOI: 10.3969/j.issn.1001-5256.2023.03.032
Abstract(841) HTML (306) PDF (2670KB)(112)
Abstract:
In recent years, liver cancer stem cells (LCSC) have been considered one of the main causes of treatment failure and recurrence of hepatocellular carcinoma (HCC). Many studies have shown that LCSC are a small fraction of cells with the abilities of self-renewal, differentiation, and tumorigenesis in...
Association of folic acid with the development and progression of liver cancer
Yingwen LI, Li SHI, Min LIU, Hao YUAN, Ya ZHENG, Yuping WANG, Qinghong GUO
2023, 39(3): 693-698. DOI: 10.3969/j.issn.1001-5256.2023.03.033
Abstract(670) HTML (568) PDF (2215KB)(114)
Abstract:
So far, liver cancer is still a highly malignant tumor with a high incidence rate in China, and it seriously affects the life and health of Chinese people. Previous studies have shown that the development of liver cancer is associated with various factors such as virus, smoking, drinking, and nonalc...
Role of stem cell-derived exosomes in treatment of liver diseases
Zhuoran WANG, Bing ZHU, Limei YU, Shaoli YOU
2023, 39(3): 699-706. DOI: 10.3969/j.issn.1001-5256.2023.03.034
Abstract(812) HTML (336) PDF (2300KB)(119)
Abstract:
The liver is easily affected by a variety of factors to induce liver damage, which can cause disorders in the synthesis, detoxification, metabolism, and biotransformation functions of the liver in severe cases, and at present, there is still a lack of efficient clinical treatment methods for end-sta...
Role of gasdermin D in the pathological progression of liver diseases
Feiyan LI, Minggang WANG, Dewen MAO, Xiongbin GUI
2023, 39(3): 707-712. DOI: 10.3969/j.issn.1001-5256.2023.03.035
Abstract(605) HTML (91) PDF (1767KB)(28)
Abstract:
As a novel star molecule, gasdermin D (GSDMD) plays an important role in the amplification of immune inflammatory response and the process of pyroptosis. After being cleaved and activated by caspase-1, the N-terminal of GSDMD is rapidly released, which anchors on the cell membrane and forms pores, t...
Trends in nano-antimicrobial therapy for severe liver disease with infection
Zhenqun LUO, Xinhua LUO
2023, 39(3): 713-717. DOI: 10.3969/j.issn.1001-5256.2023.03.036
Abstract(522) HTML (140) PDF (1748KB)(76)
Abstract:
Severe liver disease with infection has always been a key and difficult point in clinical treatment. Through continuous exploration of nanomaterials, researchers have found that nanomaterials can achieve targeted antibacterial and immunomodulatory effects due to their special physicochemical propert...
Role of A-kinase anchor protein 12 in chronic liver diseases
Haijian DONG, Hui LI, Yujing TAO, Jialing GUO, Yuru ZHONG, Zijian ZENG
2023, 39(3): 718-722. DOI: 10.3969/j.issn.1001-5256.2023.03.037
Abstract(417) HTML (119) PDF (1987KB)(88)
Abstract:
A-kinase anchor protein 12 (AKAP12) is a scaffold protein that improves the specificity and efficiency of spatio-temporal signals by assembling intracellular signal proteins into specific complexes. In recent years, the role of AKAP12 in chronic liver diseases has attracted more and more attention. ...
Advances in the treatment of iatrogenic bile duct injury
GULIMILA·Yasenjiang, TUERGANAILI·Aji
2023, 39(3): 723-728. DOI: 10.3969/j.issn.1001-5256.2023.03.038
Abstract(432) HTML (229) PDF (1755KB)(102)
Abstract:
Iatrogenic bile duct injury (IBDI) refers to bile duct injury accidentally caused by medical factors such as surgical operation or other invasive operations during treatment. With the gradual maturity of surgical operation and minimally invasive techniques, the treatment of bile duct injury now incl...
Thanks
Current reviewers
2023, 39(3): 683-683. DOI: 10.3969/j.issn.1001-5256.2023.03.zhixie1
Abstract(268) HTML (127) PDF (781KB)(55)
Abstract:
Guideline
Guidelines on the management of esophagogastric variceal bleeding in cirrhotic portal hypertension
Chinese Society of Hepatology, Chinese Society of Gastroenterology, Chinese Society of Digestive Endoscopology of Chinese Medical Association
2023, 39(3): 527-538. DOI: 10.3969/j.issn.1001-5256.2023.03.znygf
Abstract(1387) HTML (197) PDF (2570KB)(711)
Abstract:

In order to standardize the diagnosis, treatment and management of esophagogastric variceal bleeding (EVB) in cirrhotic portal hypertension, the Chinese Society of Hepatology, Chinese Society of Gastroenterology, and Chinese Society of Digestive Endoscopology of Chinese Medical Association organized...
    

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