Research advances in mechanisms and intervention of hepatic ischemia-reperfusion injury

Wang QingQing; Zhao Xin; Chen YuChao; Dou Jian

doi:10.3969/j.issn.1001-5256.2016.06.049

Issue 6

Jun. 2016

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > Journal of Clinical Hepatology > 2016 > 32(6): 1225-1229

PDF( 1587 KB)

Research advances in mechanisms and intervention of hepatic ischemia-reperfusion injury

DOI: 10.3969/j.issn.1001-5256.2016.06.049

Research funding:

Published Date: 2016-06-20

Abstract

Abstract

Hepatic ischemia- reperfusion injury(HIRI) is a process caused by the combined effect of various factors,and to some extent,it limits the development of liver surgery.In- depth studies on mechanisms of HIRI and the development of reasonable therapeutic strategies have positive effects on the prognosis of patients.This article introduces the pathogenesis of HIRI,including calcium overload,Kupffer cells,microcirculation disturbance,production of reactive oxygen species,complement,non- coding RNA,and various cytokines,and the combined effect of these factors induces the necrosis and apoptosis of hepatocytes.In addition,as a second mode of cell death,autophagy is also involved in HIRI.Due to the complex mechanism of HIRI and many factors involved,intervention should be given from various aspects.This article points out that with the development of intervention such as ischemic pretreatment,mild hypothermia and hydrogen,the new therapeutic methods are expected to bring new thoughts to the clinical intervention of HIRI.
- liver diseases,
- reperfusion injury,
- review

FullText(HTML)

References(38)

References

[1]GUAN LY,FU PY,LI PD,et al.Mechanisms of hepatic ischemia-reperfusion injury and protective effects of nitric oxide[J].World J Gastrointest Surg,2014,6(7):122-128.

[2]WICZER BM,MARCU R,HAWKINS BJ.KB-R7943,a plasma membrane Na(+)/Ca(2+)exchanger inhibitor,blocks opening of the mitochondrial permeability transition pore[J].Biochem Biophys Res Commun,2014,444(1):44-49.

[3]QIAO YL,QIAN JM,WANG FR,et al.Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells[J].J Surg Res,2014,187(2):653-659.

[4]STEWART RK,DANGI A,HUANG C,et al.A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion-and endotoxin-induced acute liver injury[J].J Hepatol,2014,60(2):298-305.

[5] ABU-AMARA M,YANG SY,TAPURIA N,et al.Liver ischemia/reperfusion injury:processes in inflammatory networks---a review[J].Liver Transpl,2010,16(9):1016-1032.

[6]GAO J,CHEN G,LYU L.Protective role and immunoregulatory effect of CXCR3 in hepatic ischemia-reperfusion injury[J].J Clin Hepatol,2014,30(8):790-794.(in Chinese)高俊,陈功,吕龙.CXCR3在肝脏缺血再灌注损伤中的保护作用及对Th细胞亚群的调节[J].临床肝胆病杂志,2014,30(8):790-794.

[7] ABU-AMARA M,YANG SY,TAPURIA N,et al.Liver ischemia/reperfusion injury:processes in inflammatory networks-a review[J].Liver Transpl,2010,16(9):1016-1032.

[8] PAPADOPOULOS D,SIEMPIS T,THEODORAKOU E,et al.Hepatic ischemia and reperfusion injury and trauma:current concepts[J].Arch Trauma Res,2013,2(2):63-70.

[9] LI J,LI RJ,LYU GY,et al.The mechanisms and strategies to protect from hepatic ischemia-reperfusion injury[J].Eur Rev Med Pharmacol Sci,2015,19(11):2036-4207.

[10] MARSHALL KM,HE S,ZHONG Z,et al.Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy[J].J Exp Med,2014,211(9):1793-1805.

[11]SAIDI RF,RAJESHKUMAR B,SHARIFTABRIZI A,et al.Human C1 inhibitor attenuates liver ischemia-reperfusion injury and promotes liver regeneration[J].J Surg Res,2014,187(2):660-666.

[12] JIANG W,KONG L,NI Q,et al.miR-146a ameliorates liver ischemia/reperfusion injury by suppressing IRAK1 and TRAF6[J].PLo S One,2014,9(7):e101530.

[13]HERNANDEZ-ALEJANDRO R,ZHANG X,CROOME KP,et al.Reduction of liver ischemia reperfusion injury by silencing of TNF-alpha gene with shRNA[J].J Surg Res,2012,176(2):614-620.

[14] HUANG X,GAO Y,QIN J,et al.The role of miR-34a in the hepatoprotective effect of hydrogen sulfide on ischemia/reperfusion injury in young and old rats[J].PLo S One,2014,9(11):e113305.

[15] CHEN Z,JIA S,LI D,et al.Silencing of long noncoding RNAAK139328 attenuates ischemia/reperfusion injury in mouse livers[J].PLo S One,2013,8(11):e80817.

[16]NIKOLETOPOULOU V,MARKAKI M,PALIKARAS K,et al.Crosstalk between apoptosis,necrosis and autophagy[J].Biochim Biophys Acta,2013,1833(12):3448-3459.

[17]SHEN M,LU J,DAI W,et al.Ethyl pyruvate ameliorates hepatic ischemia-reperfusion injury by inhibiting intrinsic pathway of apoptosis and autophagy[J].Mediators Inflamm,2013,2013(1):2409-2420.

[18] TAKAMURA A,KOMATSU M,HARA T,et al.Autophagy-deficient mice develop multiple liver tumors[J].Genes Dev,2011,25(8):795-800.

[19]QIAO PF,YAO L,ZHANG XC,et al.Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy[J].World J Gastroenterol,2015,21(45):12822-312824.

[20] LI J,WANG F,XIA Y,et al.Astaxanthin pretreatment attenuates hepatic ischemia reperfusion-induced apoptosis and autophagy via the ROS/MAPK pathway in mice[J].Mar Drugs,2015,13(6):3368-3387.

[21] BOYA P,REGGIORI F,CODOGNO P.Emerging regulation and functions of autophagy[J].Nat Cell Biol,2013,15(7):713-720.

[22]CHENG P,WANG F,CHEN K,et al.Hydrogen sulfide ameliorates ischemia/reperfusion-induced hepatitis by inhibiting apoptosis and autophagy pathways[J].Mediators Inflamm,2014,2014(2):935251.

[23] KIM JS,NITTA T,MOHUCZY D,et al.Impaired autophagy:a mechanism of mitochondrial dysfunction in anoxic rat hepatocytes[J].Hepatology,2008,47(5):1725-1736.

[24] ELMORE SP,QIAN T,GRISSOM SF,et al.The mitochondrial permeability transition initiates autophagy in rat hepatocytes[J].FASEB J,2001,15(12):2286-2287.

[25]CHU MJ,VATHER R,HICKEY AJ,et al.Impact of ischemic preconditioning on outcome in clinical liver surgery:a systematic review[J].Biomed Res Int,2015,2015:370451.

[26]CHU MJ,VATHER R,HICKEY AJ,et al.Impact of ischaemic preconditioning on experimental steatotic livers following hepatic ischaemia-reperfusion injury:a systematic review[J].HPB(Oxford),2015,17(1):1-10.

[27]O'NEILL S,LEUSCHNER S,Mc NALLY SJ,et al.Meta-analysis of ischaemic preconditioning for liver resections[J].Br J Surg,2013,100(13):1689-700.

[28]YE QF,HU L,XIA ZP,et al.Moderate hypothermia reduces hepatic ischemia-reperfusion injury[J].Chin J Hepatobiliary surg,2015,21(8):555-558.(in Chinese)叶啟发,胡龙,夏志平,等.亚低温对肝脏缺血再灌注损伤的防护作用研究[J].中华肝胆外科杂志,2015,21(8):555-558.

[29] LONGO L,SINIGAGLIA-FRATTA LX,WEBER GR,et al.Hypothermia is better than ischemic preconditioning for preventing early hepatic ischemia/reperfusion in rats[J].Ann Hepatol,2015,15(1):110-120.

[30]BOS EM,SNIJDER PM,JEKEL H,et al.Beneficial effects of gaseous hydrogen sulfide in hepatic ischemia/reperfusion injury[J].Transpl Int,2012,25(8):897-908.

[31] ZHANG Q,FU H,ZHANG H,et al.Hydrogen sulfide preconditioning protects rat liver against ischemia/reperfusion injury by activating Akt-GSK-3beta signaling and inhibiting mitochondrial permeability transition[J].PLo S One,2013,8(9):e74422.

[32] SHIMADA S,FUKAI M,WAKAYAMA K,et al.Hydrogen sulfide augments survival signals in warm ischemia and reperfusion of the mouse liver[J].Surg Today,2015,45(7):892-903.

[33] OHSAWA I,ISHIKAWA M,TAKAHASHI K,et al.Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals[J].Nat Med,2007,13(6):688-694.

[34]BUCHHOLZ BM,KACZOROWSKI DJ,SUGIMOTO R,et al.Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury[J].Am J Transplant,2008,8(10):2015-2024.

[35] LIU Y,YANG L,TAO K,et al.Protective effects of hydrogen enriched saline on liver ischemia reperfusion injury by reducing oxidative stress and HMGB1 release[J].BMC Gastroenterol,2014,14:12.

[36]ZHANG CB,TANG YC,XU XJ,et al.Hydrogen gas inhalation protects against liver ischemia/reperfusion injury by activating the NF-kappa B signaling pathway[J].Exp Ther Med,2015,9(6):2114-2120.

[37]LI WN,PENG CJ,SHU DJ,et al.Progress in research of liver ischemia-reperfusion injury[J].World Chin J Dig,2015,23(22):3554-3559.(in Chinese)李伟男,彭慈军,舒德军,等.肝脏缺血再灌注损伤的研究进展[J].世界华人消化杂志,2015,23(22):3554-3559.

[38]BJORNSSON B,BOJMAR L,OLSSON H,et al.Nitrite,a novel method to decrease ischemia/reperfusion injury in the rat liver[J].World J Gastroenterol,2015,21(6):1775-1783.

Relative Articles

[1]	Jiaxin LIANG, Baolin XU, Yu CHENG, Yong WEI. Role of ferroptosis in hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2024, 40(8): 1693-1698. doi: 10.12449/JCH240830
[2]	Jinrui ZHANG, Hao WU, Yi BAI, Yamin ZHANG. Effect of trimetazidine on a rat model of bile duct ischemia-reperfusion injury and its mechanism[J]. Journal of Clinical Hepatology, 2022, 38(11): 2546-2550. doi: 10.3969/j.issn.1001-5256.2022.11.021
[3]	Zhen LI, Ke WANG, Kaiqiang WANG, Kexian YU. Research advances in targeting autophagy to alleviate hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2022, 38(1): 210-214. doi: 10.3969/j.issn.1001-5256.2022.01.037
[4]	Zhen LI, Yihao ZENG, Ke WANG, Kaiqiang WANG, Kexian YU. Research advances in the prevention and treatment of hepatic ischemia-reperfusion injury with traditional Chinese medicine components[J]. Journal of Clinical Hepatology, 2022, 38(2): 471-476. doi: 10.3969/j.issn.1001-5256.2022.02.044
[5]	Xiaokang YI, Yichao DU, Baolin QIAN, Zhiwei HUANG, Qiu LI, Wenguang FU, Jian WEN. Protective effect of tanshinone I in a mouse model of hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2021, 37(1): 105-109. doi: 10.3969/j.issn.1001-5256.2021.01.021
[6]	Yangyang WANG, Xueying PENG, Jie MENG, Boran AN, Wenjuan HE, Sucai LU, Yan CHEN, Liwen KONG, Chuan NIU, Cong LIU, Wei HUANG, Yingjian HOU. Protective effect of resolvin D1 pretreatment in a rat model of hepatic ischemia-reperfusion injury and its mechanism[J]. Journal of Clinical Hepatology, 2021, 37(6): 1373-1378. doi: 10.3969/j.issn.1001-5256.2021.06.030
[7]	Mi Kai, Huang Rui. Protective effect of urolithin A pretreatment in a rat model of hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2020, 36(8): 1783-1787. doi: 10.3969/j.issn.1001-5256.2020.08.021
[8]	Yang LongCan, Zhang XuYang, Pan NingBo, Yu Xi, Li JiWei, Zhang Ying. Effect of rapamycin on the expression of autophagy-related proteins Unc-51 like autophagy activating kinase 1 and microtubule-associated protein 1 light chain 3 in hepatic ischemia-reperfusion injury and its significance[J]. Journal of Clinical Hepatology, 2019, 35(10): 2261-2265. doi: 10.3969/j.issn.1001-5256.2019.10.026
[9]	Luo YanQing, Feng ChunLin, Mei Yong, Du Chao, Ceng PengFei, Wang Jun, Wang GuoXing, Zhao Liang, Leng Kai. Protective effect of hepatocyte growth-promoting factor against liver ischemia-reperfusion injury in rats and its mechanism of action[J]. Journal of Clinical Hepatology, 2019, 35(2): 364-367. doi: 10.3969/j.issn.1001-5256.2019.02.024
[10]	Zhang ShiLong, Peng CiJun, Feng ZanJie, Gao WeiDong, Duan YuLing, Fan GuoXin. Mechanism of action of microRNA in the regulation of hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2019, 35(7): 1629-1631. doi: 10.3969/j.issn.1001-5256.2019.07.045
[11]	Liu Jian, Li Li, Wang XiaoChuan, Zhang ShengNing, Li LaiBang, Mang YuanYi, Gao Yang, Chen YongLin, Ren Gang, Li Wang. Mild hypothermia exerts a protective effect against hepatic ischemia-reperfusion injury in rats by activating the PI3K/Akt signaling pathway[J]. Journal of Clinical Hepatology, 2019, 35(4): 846-851. doi: 10.3969/j.issn.1001-5256.2019.04.027
[12]	Zheng JianHao, Dai ChaoLiu. Influence of ischemia-reperfusion injury on liver cancer and related mechanism[J]. Journal of Clinical Hepatology, 2019, 35(6): 1369-1373. doi: 10.3969/j.issn.1001-5256.2019.06.042
[13]	Gao WeiDong, Feng ZanJie, Peng CiJun, Li Yang, Wu Bo, Geng Xin. Association between high-mobility group box B1 and hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2019, 35(3): 669-671. doi: 10.3969/j.issn.1001-5256.2019.03.049
[14]	Wang JingYuan, Li ShengWei, Gong JianPing, Jiang DeQuan. Role of silent information regulator 1 in hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2019, 35(6): 1388-1391. doi: 10.3969/j.issn.1001-5256.2019.06.047
[15]	Chen BaoHe, Li WenMei. Effect of ulinastatin combined with ischemic preconditioning on hepatic ischemia-reperfusion injury in rats[J]. Journal of Clinical Hepatology, 2018, 34(2): 368-372. doi: 10.3969/j.issn.1001-5256.2018.02.030
[16]	Xu Feng, Liu XiaoLin, Wang Chao, Dai ChaoLiu. Protective effect of prostaglandin E1 pretreatment against liver ischemia-reperfusion injury in rats with cholestasis[J]. Journal of Clinical Hepatology, 2017, 33(5): 899-904. doi: 10.3969/j.issn.1001-5256.2017.05.022
[17]	Gao Jun, Chen Gong, Lu: Long. Protective role and immunoregulatory effect of CXCR3 in hepatic ischemia- reperfusion injury[J]. Journal of Clinical Hepatology, 2014, 30(8): 790-794. doi: 10.3969/j.issn.1001-5256.2014.08.023
[18]	Wu Gang, Zheng Jie, Hu GuoXin, Peng YanZhong. Role of liver nonparenchymal cells in hepatic ischemia-reperfusion injury[J]. Journal of Clinical Hepatology, 2014, 30(12): 1366-1369. doi: 10.3969/j.issn.1001-5256.2014.12.033
[19]	Sun KeYan, Teng Fei, Guo WenYuan, Liu Fang, Fu ZhiRen. Protective role of β- catenin gene in hepatic ischemia- reperfusion injury among mice and its mechanism[J]. Journal of Clinical Hepatology, 2013, 29(10): 787-789. doi: 10.3969/j.issn.1001-5256.2013.10.016
[20]	Tang JianJun, Jiang Yong, Luo GuangHua, Yuan Bo. The protective effect of different-time-ischemic preconditioning on the reperfusion injury in fatty livers in rats[J]. Journal of Clinical Hepatology, 2011, 27(12): 1308-1311.

Supplements(0)

Cited By

Cited by

Periodical cited type(23)

1.	韦丽娟，陶品月. 浅低温调控miRNA在肝脏缺血再灌注损伤中的研究进展. 医学研究与战创伤救治. 2024(03): 332-336 .
2.	朱山飞，张建松，郝定盈，苑伟，吴帆，王百林. 柴胡皂苷d通过抑制炎性反应减轻大鼠肝脏缺血再灌注损伤. 中华实验外科杂志. 2024(09): 2006-2010 .
3.	易小康，杜毅超，钱保林，黄治伟，李秋，付文广，温剑. 丹参酮Ⅰ在肝缺血再灌注损伤小鼠模型中的保护作用. 临床肝胆病杂志. 2021(01): 105-109 . 本站查看
4.	王永宽，田新雁，苏娟，庞博，周萍. 分心木提取物对大鼠HIRI的保护作用初探. 大理大学学报. 2021(02): 25-28 .
5.	杨超君，王跃武，周开珩. 川陈皮素防治肝缺血再灌注损伤的作用机制研究. 中草药. 2021(08): 2343-2350 .
6.	张国欣，李能莲，舍雅莉，程小丽，张凌云，谭萍. 黄芪多糖对大鼠肝脏缺血再灌注损伤的影响. 中国中医药科技. 2020(03): 376-379 .
7.	卢建升，田新雁，苏娟，吕兴，王永宽，庞博，周萍. 大鼠HIRI模型中氧化损伤和Hcy含量的研究. 大理大学学报. 2020(04): 12-15 .
8.	常顺伍，韩晓玉，宫晓光，王葆春. 重组促红细胞生成素对脂肪肝缺血再灌注损伤大鼠细胞凋亡和炎症因子的影响. 海南医学. 2020(14): 1769-1773 .
9.	李小辉，文武，万仁华，单人锋，熊远鹏，罗来辉，刘惟棋，宋胜江，董晓渊. 间歇性全入肝血流阻断与区域性入肝血流阻断在大肝癌腹腔镜肝切除术中的应用比较. 山东医药. 2020(35): 49-51 .
10.	王伟，陆昌友，朱涛，任锐，陈伟平，王宗云. 异甘草酸镁对肝癌病人肝切除术后肝脏缺血再灌注损伤的影响. 腹部外科. 2019(01): 23-26+39 .
11.	杨诺，李文. 血红素加氧酶1对肝脏缺血再灌注损伤的保护作用. 医学综述. 2019(12): 2289-2293+2298 .
12.	张良. 右美托咪定对高血压合并肝癌患者术后肝肾功能及血浆miR-122、miR-192的影响. 检验医学与临床. 2019(13): 1832-1836 .
13.	付洋，傅全威，韩涛. 低氧诱导因子对肝缺血再灌注损伤的保护作用研究. 中国临床实用医学. 2019(04): 58-59-60-61 .
14.	刘晓军，叶锋，李晓智，陈静，林瑶，沙拉木，吴晓欣，伍宇平，陈昱，杨惠玲. 二甲双胍对大鼠肝脏缺血再灌注损伤抗氧化保护作用. 海峡药学. 2018(08): 14-17 .
15.	陈宝鹤，李文美. 乌司他丁联合缺血预处理对大鼠肝缺血再灌注损伤的影响. 临床肝胆病杂志. 2018(02): 368-372 . 本站查看
16.	王树森，郑越. 川芎嗪在器官移植中防治缺血-再灌注损伤的研究进展. 器官移植. 2018(05): 402-404 .
17.	崔龙海，李浩，韩龙哲，李哲浩. 乌司他丁预处理对肝缺血再灌注大鼠急性肾损伤的预防作用. 山东医药. 2018(31): 52-55 .
18.	郑伟，海军，宋晓雪，常虎林，杜立学. 甲基莲心碱对肝缺血再灌注损伤模型小鼠氧化应激和炎症反应的影响. 中国药房. 2018(15): 2068-2072 .
19.	崔璀，杨立群. 鞘内注射瑞芬太尼对肝缺血再灌注影响研究. 临床军医杂志. 2017(09): 922-925 .
20.	张宁，郭振中，程燕. 右美托咪定对肝叶切除患者肝功能、细胞因子及氧化应激的影响. 临床肝胆病杂志. 2017(03): 507-511 . 本站查看
21.	滕旭，丁凡，陈文捷，许赤. 高剂量西罗莫司可能通过促进细胞自噬对老年小鼠肝脏缺血-再灌注损伤起保护作用. 器官移植. 2017(05): 349-354 .
22.	宋娟，田小霞，李宝红，王东，孟董超，卢彦珍. 白藜芦醇通过高迁移率族蛋白B1抗大鼠肝脏缺血再灌注损伤的作用及机制. 中国临床药理学与治疗学. 2017(11): 1215-1220 .
23.	薛佩彤，李宏. 中药预处理保护肝脏缺血再灌注损伤的研究进展. 中国中西医结合外科杂志. 2016(05): 511-514 .

Other cited types(22)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (1933) PDF downloads(462)

Research advances in mechanisms and intervention of hepatic ischemia-reperfusion injury

DOI: 10.3969/j.issn.1001-5256.2016.06.049