The establishment of rabbit VX2 hepatic tumor model and the application of nano-scale microbubble contrast agent in the diagnosis of this model

Jiang Han; Wang XueFeng; Wang ZiHao; Xu Bin; Shi WeiBin

Issue 7

Jul. 2011

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Article Navigation > Journal of Clinical Hepatology > 2011 > 27(7): 746-748

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The establishment of rabbit VX2 hepatic tumor model and the application of nano-scale microbubble contrast agent in the diagnosis of this model

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Published Date: 2011-07-20

Abstract

Abstract

Objective To investigate the application of nano-scale microbubble contrast agent in hepatocarcinoma diagnosis by building a primary or metastatic liver carcinoma animal models.Methods The rabbit hepatocarcinoma model was established through vaccinating tumor tissue in liver.Tumor can be developed by injecting nano-scale microbubble contrast agent from portal vein.Results The mission success rate of model establishment is high to 83.3%, the imaging of major vascular and tumor in liver is enhanced when using the 5MHz frequency mode.Conclusion Targeted nano ultrasound contrast agents are specific and sensitive, nanoscale for ultrasound microbubble contrast enhancement is completely feasible.
- disease models,
- animal,
- liver neoplasms,
- experimental,
- neoplasm seeding

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References

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The establishment of rabbit VX2 hepatic tumor model and the application of nano-scale microbubble contrast agent in the diagnosis of this model