Objective To analyse dietary intake of selenium and serum selenium levels in patients with different types of chronic liver diseases,and to explore the relationship between selenium and severity of liver diseases. Methods Seventy- four patients admitted to Beijing You An Hospital from August 2008 to October 2014,as well as 16 healthy persons as healthy control( HC) group,were recruited in this study.Based on liver disease types,these patients were divided into chronic hepatitis( CH) group( n = 23),liver cirrhosis( LC) group( n = 27),and acute- on- chronic liver failure( ACLF) group( n = 24). Dietary intake of selenium was calculated on admission by dietary assessment software,and serum selenium levels were measured by inductively coupled plasma- atomic emission spectroscopy. Comparison of continuous data between groups was made by one- way ANOVA; comparison of categorical data between groups was made by χ2test; the correlation between variables was determined by Pearson correlation analysis. Results The dietary selenium intake in the HC group was 45. 45 ± 18. 10 μg.Compared with the HC group,the CH group,LC group,and ACLF group had insufficient dietary intake of selenium( 37. 69 ± 11. 30 μg,32. 65 ± 13. 55 μg,and 28. 95 ± 13. 30 μg,respectively). Dietary selenium intake gradually decreased with the progression of liver disease.Compared with the HC group,the LC group and ACLF group had significantly lower dietary selenium intake( P = 0. 004 and 0. 000,respectively). Serum selenium in the HC group was 0. 17 ± 0. 04 μg / ml. Compared with the HC group,the CH group,LC group,and ACLF group had significantly lower serum selenium levels( 0. 12 ± 0. 05 μg / ml,P = 0. 007; 0. 11 ± 0. 06 μg / ml,P = 0. 000; 0. 13 ± 0. 05 μg /ml,P = 0. 015). Serum selenium in the LC group was reduced most among these groups. Furthermore,serum selenium was significantly associated with prealbumin level,white blood cell count,and platelet count( r = 0. 229,P = 0. 030; r = 0. 213,P = 0. 044; r = 0. 255,P =0. 015). Conclusion With the progression of liver disease,serum selenium and dietary intake of selenium decrease gradually. It is meaningful to monitor and provide supplementary selenium in patients with chronic liver diseases during clinical practice.
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