Diagnosis and treatment of fever-related recurrent acute liver failure in children

Zhongdie LI; Jiaqi LI; ABUDUXIKUER Kuerbanjiang

doi:10.3969/j.issn.1001-5256.2022.02.003

Volume 38 Issue 2

Feb. 2022

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Article Navigation > Journal of Clinical Hepatology > 2022 > 38(2): 264-267

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Diagnosis and treatment of fever-related recurrent acute liver failure in children

DOI: 10.3969/j.issn.1001-5256.2022.02.003

Department of Hepatology, Children's Hospital of Fudan University, Shanghai 201102, China

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Corresponding author: ABUDUXIKUER Kuerbanjiang, k_abuduxikuer@fudan.edu.cn
Received Date: 2021-12-17
Accepted Date: 2021-12-20
Published Date: 2022-02-20

Abstract

Abstract

Acute liver failure (ALF) in infants and children is a severe life-threatening disease caused by multiple etiologies. Recurrent acute liver failure (RALF) is defined as the occurrence of acute liver injury two or more times, with at least one episode meeting the diagnostic criteria for ALF. Biochemical parameters usually return to normal between acute liver injury episodes in children with RALF. Clinical etiologies of RALF include infections, immunologic disorders, drug, and toxin, as well as hereditary or metabolic disorders, and some episodes of RALF caused by hereditary liver disorders are always associated with fever. This article discusses the diagnosis and treatment of fever-related RALF caused by genetic defects of NBAS, SCYL1, and RINT1.
- Liver Failure, Acute,
- Fever,
- Genetic Diseases, Inborn

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References(18)

References

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Diagnosis and treatment of fever-related recurrent acute liver failure in children

DOI: 10.3969/j.issn.1001-5256.2022.02.003